Evidence map›Paper›PMID 31041107›Full record

ArticleCanadian journal of kidney health and disease2019

A Holistic Approach to Risk for Early Kidney Injury in Indigenous Youth With Type 2 Diabetes: A Proof of Concept Paper From the iCARE Cohort.

Allison B Dart, Brandy Wicklow, Tom D Blydt-Hansen, Elizabeth A C Sellers, Sayma Malik, Dan Chateau, Atul Sharma, Jonathan M McGavock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Complications and Treatment of Early-Onset Type 2 Diabetes.International journal of endocrinology and metabolism · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Ambulatory Blood Pressure Monitoring in Pediatrics.Current hypertension reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Allison B DartDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0000-0002-4718-9408
Brandy WicklowDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
Tom D Blydt-HansenDepartment of Pediatrics, The University of British Columbia, Winnipeg, MB, Canada.
Elizabeth A C SellersDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
Sayma MalikDepartment of Clinical Psychology, University of Manitoba, Winnipeg, Canada.
Dan ChateauDepartment of Community Health Sciences, University of Manitoba, Winnipeg, Canada.
Atul SharmaDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
Jonathan M McGavockDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
Children's Hospital Research Institute of Manitoba · CAUniversity of Manitoba · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndigenous youth with type 2 diabetes (T2D) are disproportionately affected by early onset albuminuria and are at high risk of kidney failure in early adulthood. Traditional biological approaches have failed to fully explain the renal morbidity seen in this population. The

objectiveThe objective of this study was to evaluate the iCARE analytic framework which evaluates relationships between biological factors, mental health, inflammation, and albuminuria utilizing a structural equation modeling (SEM) approach.

methodsThe first 187 youth with T2D (10-25 years) from the Manitoba iCARE cohort are presented here to evaluate our theoretical and analytic framework. An SEM was chosen to evaluate the statistical significance of proposed associations. The primary outcome was a nonorthostatic urine albumin:creatinine ratio ≥2 mg/mmol. Main exposures (ie, latent factors) included psychological health (distress, perceived stress, positive mental health and resilience), hypertension (24 hour monitored), and inflammatory markers (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], fibrinogen). Hemoglobin A1c (HbA1c) and duration of diabetes were covariates.

resultsWithin the initial cohort (median age = 15 years, duration of diabetes = 2.3 years, 66.8% female), 30.5% (n = 57) had nonorthostatic albuminuria (ALB), and the majority of ALB was persistent (confirmed in 2/3 samples over a 6-month period; n = 47). Youth with ALB had higher HbA1c (10.9% vs 8.9%;

conclusionsAlbuminuria is highly prevalent in Indigenous youth with T2D. This preliminary analysis supports a theoretical framework linking glycemic control, hypertension, and inflammation, potentially mediated by psychological factors with albuminuria. These data support the need for more holistic models of evaluation and care for youth with T2D and multifactorial interventions to prevent complications.

Indexed as

albuminuriaholisticstructural equation modeltype 2 diabetesyouth

Identifiers

PMID31041107
PMCPMC6477761
OpenAlexW2941570251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.