Evidence map›Paper›PMID 31040823›Full record

ArticleFrontiers in endocrinology2019

Astragalin Promotes Osteoblastic Differentiation in MC3T3-E1 Cells and Bone Formation

Li Liu, Dan Wang, Yao Qin, Maolei Xu, Ling Zhou, Wenjuan Xu, Xiaona Liu, Lei Ye, Shijun Yue, Qiusheng Zheng and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Flavonoids ofPreventive nutrition and food science · 2026
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  3. Review
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  5. Comparative analysis ofFrontiers in pharmacology · 2025
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  7. Article
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  9. Article
  10. Article
  11. Isolation of Pro-Osteogenic Compounds fromInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Research advances in the role of MAPK cascade in regulation of cell growth, immunity, inflammation, and cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  16. Article
  17. [Effects and mechanism of morroniside on osteogenic differentiation and proliferation of mouse MC3T3-E1 cells].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Li LiuSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Dan WangSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Yao QinSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Maolei XuSchool of Pharmacy, Binzhou Medical University, Yantai, China.
Ling ZhouSchool of Pharmacy, Binzhou Medical University, Yantai, China.
Wenjuan XuSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Xiaona LiuSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Lei YeSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Shijun YueSchool of Pharmacy, Guangdong Medical University, Dongguan, China.
Qiusheng ZhengSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Defang LiSchool of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.
Binzhou University · CNBinzhou Medical University · CNGuangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astragalin (AG) is a biologically active flavonoid compound that can be extracted from a number of medicinal plants. However, the effects of AG on osteoblastic differentiation in mouse MC3T3-E1 cells and on bone formation

Indexed as

AstragalinBMP-2bone formationMAPKMC3T3-E1 cellsosteoblastic differentiation

Identifiers

PMID31040823
PMCPMC6476984
OpenAlexW2938168607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.