ArticleDose-response : a publication of International Hormesis Society
Analysis of Circular RNA Expression Profile in HEK 293T Cells Exposed to Ionizing Radiation.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Pathway-based analyses of gene expression profiles at low doses of ionizing radiation.Frontiers in bioinformatics · 2024Article
- Emerging Landscape of Preclinical Models for Studying COVID-19 Neurologic Diseases.ACS pharmacology & translational science · 2023Review
- Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma.Cancer cell international · 2022Review
- Circular RNAs in kidney disease and cancer.Nature reviews. Nephrology · 2021Review
- Review
- Integrated analysis of circRNA-miRNA-mRNA network reveals potential prognostic biomarkers for radiotherapies with X-rays and carbon ions in non-small cell lung cancer.Annals of translational medicine · 2020Article
- Circular RNA in renal diseases.Journal of cellular and molecular medicine · 2020Review
- Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance.Molecular cancer · 2020Review
- Role of non-coding RNAs and RNA modifiers in cancer therapy resistance.Molecular cancer · 2020Review
- Integrated Analysis of the Altered lncRNAs and mRNAs Expression in 293T Cells after Ionizing Radiation Exposure.International journal of molecular sciences · 2019Article
- Analysis of circRNA-miRNA-mRNA Regulatory Network in Peripheral Blood of Radiation Workers.Dose-response : a publication of International Hormesis SocietyArticle
- Positive Cofactor 4 as a Potential Radiation Biodosimeter for Early Assessment.Dose-response : a publication of International Hormesis SocietyArticle
- Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2.Frontiers in immunologyReview
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation therapy is one of the most common cancer treatments. It is important to understand how cells respond to ionizing radiation (IR) to improve therapeutic efficacy. Circular RNAs (circRNAs) recently have been found to regulate a variety of cellular processes. However, it is poorly defined that their expression pattern and their identity in cells following IR exposure. Here, we performed high-throughput sequencing and comprehensive analysis of circRNA expression in human embryonic kidney (HEK) 293T cells before and after irradiation. We identified totally 5592 circRNAs and discovered 1038 new circRNAs. We found 158 circRNAs with significantly differential expression after IR exposure. Among them, there were 61 upregulated and 97 downregulated circRNAs. Using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway, and circRNA-microRNA-messenger RNA network analyses, we found the differentially expressed circRNAs might be involved in the signal pathways of oxidative phosphorylation, epithelial growth factor receptor (EGFR) tyrosine kinase inhibitor resistance, and mammalian target of rapamycin (mTOR) signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.