ArticleCancer management and research2019
Tumor location of the central and nipple portion is associated with impaired survival for women with breast cancer.
Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Sociodemographic Profile, Reproductive Factors and Presentation Pattern in Breast Cancer Patients from North India: A Hospital Based Study.Journal of pharmacy & bioallied sciences · 2025Article
- Clinical Implication of Subcategorizing T2 Category in Metaplastic Breast Cancer.Journal of breast cancer · 2025Article
- Errors Induced by Partial Pathlength Variations Due to Mammographic Compression in Dynamic Diffuse Optical Breast Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Comparison of long-term oncologic outcomes of central lumpectomy and conventional breast-conserving surgery for invasive breast cancer: propensity score matching analysis.Breast cancer research and treatment · 2024Article
- Comparison of long-term oncological outcomes after central lumpectomy versus nipple-sparing breast-conserving surgery for centrally located breast cancer: a propensity score-matched study.Breast cancer research and treatment · 2024Article
- Oncoplastic Breast Conservation for Central Tumors: Definition, Classification, and the Analysis of Single Institution Experience.Plastic and reconstructive surgery. Global open · 2024Article
- Intramammary Tumor Location and Ipsilateral Lymphatic Spread in Early Breast Cancer Patients Using One-Step Nucleic Acid Amplification (OSNA) Assay.The breast journal · 2024Observational
- Novel computational biology modeling system can accurately forecast response to neoadjuvant therapy in early breast cancer.Breast cancer research : BCR · 2023Article
- Article
- Editorial: Recent advancements in neoadjuvant chemotherapy for specific breast cancer subtypes.Frontiers in oncology · 2022Article
- Breast Reconstruction Does Not Affect the Survival of Patients with Breast Cancer Located in the Central and Nipple Portion: A Surveillance, Epidemiology, and End Results Database Analysis.Frontiers in surgery · 2022Article
- Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion.Frontiers in surgery · 2022Article
- Tumor Microenvironment Characterization in Breast Cancer Identifies Prognostic and Neoadjuvant Chemotherapy Relevant Signatures.Frontiers in molecular biosciences · 2021Article
- Breast-Conserving Therapy Has Better Prognosis for Tumors in the Central and Nipple Portion of Breast Cancer Compared with Mastectomy: A SEER Data-Based Study.Frontiers in oncology · 2021Article
- Predictive Factors Among Clinicopathological Characteristics for Sentinel Lymph Node Metastasis in T1-T2 Breast Cancer.Cancer management and research · 2021Article
- Prognostic significance of the primary tumor site and immune indexes in patients with estrogen receptor-positive, human epidermal growth factor receptor-2-negative breast cancer.Gland surgery · 2020Article
- The role of adjuvant chemotherapy in stage I-III male breast cancer: a SEER-based analysis.Therapeutic advances in medical oncology · 2020Article
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTumor location in the breast varies, with the highest frequency in the upper outer quadrant and lowest frequency in the lower inner quadrant. Nevertheless, tumors in the central and nipple portion (TCNP) are poorly studied types of breast cancer; therefore, we aimed to clarify the clinicopathological characteristics and prognostic features of TCNP.
methodsUsing the Surveillance, Epidemiology, and End Results database, we identifed 105,037 patients diagnosed with tumor in the breast peripheral quadrant (TBPQ) (n=97,046) or TCNP (n=7,991). The chi-squared test was used to compare categorical variables across TCNP and TBPQ. Cox proportional hazard models with hazard ratios were applied to estimate the factors associated with prognosis.
resultsThe median follow-up was over 43 months. Compared with TBPQ, TCNP patients were signifcantly older (age ≥66 years: 40.4% vs 34.1%, P<0.001), with larger tumor sizes (>20 mm size: 46.9% vs 37.3%, P<0.001), higher proportions of TNM stage II-III (18.6% vs 9.9%, P<0.001), and more mastectomies (58.1% vs 37.8%, P<0.001). The breast cancer-specifc survival (BCSS)/overall survival (OS) rate was signifcantly worse for TCNP than for TBPQ. Multivariate Cox analysis showed a higher hazard ratios for TCNP over TBPQ (BCSS: hazard ratios =1.160, P=0.005, 95% CI: 1.046-1.287; OS: hazard ratios =1.301, P<0.001, 95% CI: 1.211-1.398). A subgroup analysis revealed inferior outcomes for TCNP in TNM stage II-III and breast subtype subgroup. Multivariate logistic regression indicated that TCNP was an independent contributing factor to LN metastasis.
conclusionsTCNP was associated with older age, larger tumor size, higher TNM stage, and lymph node metastasis. Compared with TBPQ, TCNP had adverse impacts on BCSS and OS.
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