ReviewAnnals of gastroenterology
Anal intraepithelial neoplasia: diagnosis, screening, and treatment.
Review in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Interventions for anal canal intraepithelial neoplasia.The Cochrane database of systematic reviews · 2025Pooled it
- Evidence for Anal Dysplasia Treatment.Clinics in colon and rectal surgery · 2026Review
- Treatment Options for Anal Neoplasia: Going from Anal Dysplasia to Anal Cancer.Clinics in colon and rectal surgery · 2026Review
- Educational Needs for Preventing and Managing Human Papillomavirus-Related Diseases in Men Living with HIV in Mexico.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025Article
- Males Have Lower Anal Pap Smear Screening in a Miami Safety-Net HIV Clinic.International journal of behavioral medicine · 2025Article
- Review
- Outcomes of endoscopic submucosal dissection for treatment of superficial anal squamous cell carcinoma: Multicenter international experience.Endoscopy international open · 2025Article
- Anal carcinoma - exploring the epidemiology, risk factors, pathophysiology, diagnosis, and treatment.World journal of experimental medicine · 2024Review
- Methylation markers for anal cancer screening: A repeated cross-sectional analysis of people living with HIV, 2015-2016.International journal of cancer · 2024Article
- Association of body mass index with anal human papillomavirus infection and histologically confirmed high-grade squamous intraepithelial lesions in people who receive services at the Anal Neoplasia Clinic in Puerto Rico.Preventive medicine reports · 2024Article
- Association of Methylated DNA Markers with High-Risk HPV Infections in Oral Site and Precancer Anal Lesions in HIV-Positive MSM.Biomedicines · 2024Article
- Clinical application of endoscopic submucosal dissection for superficially invasive squamous cell carcinoma/high-grade squamous intraepithelial lesion involving the canal anal.Techniques in coloproctology · 2024Article
- Review
- Innovation in Actinic Keratosis Assessment: Artificial Intelligence-Based Approach to LC-OCT PRO Score Evaluation.Cancers · 2023Article
- Detecting anal human papillomavirus infection in men who have sex with men living with HIV: implications of assay variability.Sexually transmitted infections · 2023Article
- Development of a multivariable prediction model for anal high-grade squamous intraepithelial lesions in persons living with HIV in Puerto Rico: a cross-sectional study.Lancet regional health. Americas · 2023Article
- Endoscopic submucosal dissection to treat squamous cell carcinoma in situ of the anal canal.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2022Article
- Anal cytology screening in men who have sex with men with HIV at a university hospital in Bogotá, Colombia.International journal of STD & AIDS · 2022Observational
- Progression of Anal Intraepithelial Neoplasia to Cancer Is Low with Anoscopy Surveillance and Treatment.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Anal cancer screening among women with HIV: provider experiences and system-level challenges.AIDS care · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anal intraepithelial neoplasia (AIN) is a premalignant lesion for anal cancer. It is more commonly found in high-risk patients (e.g., human papilloma virus (HPV)/human immunodeficiency virus infections, post-organ transplantation patients, and men who have sex with men) and development is driven by HPV infection. The incidence of AIN is difficult to estimate, but is heavily skewed by preexisting conditions, particularly in high-risk populations. The diagnosis is made from cytology or biopsy during routine examinations, and can be performed at a primary care provider's office. A pathologist can then review and classify cells, based on nucleus-to-cytoplasm ratios. The classification of low or high grade can better predict progression from AIN to anal cancer. There is little debate that AIN can develop into anal cancer, and the main rationale for treatment is to delay the progression. Significant controversy remains regarding screening, surveillance, and treatment for AIN. Management options are separated into surveillance (watchful waiting) and interventional strategies. Emerging data suggest that close patient follow up with a combination of ablative and topical treatments may offer the greatest benefit. HPV vaccination offers a unique treatment prior to HPV infection and the subsequent development of AIN, but its use after the development of AIN is limited. Ablative treatment includes excision, fulguration, and laser therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.