ArticleScientific reports2019
Comparative analysis of serologic cross-reactivity using convalescent sera from filovirus-experimentally infected fruit bats.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Systematic review on Marburg virus prevalence and persistence in animals.Frontiers in veterinary science · 2026Pooled it
- Article
- Nucleoprotein and glycoprotein based serological assays for detection of Marburg virus infections.EBioMedicine · 2026Article
- Mismatched and underrepresented: bat-virus diversity and phylogeographic bias in experimental infection studies.Frontiers in immunology · 2026Review
- Serologic evidence of orthomarburgviruses and an orthoebolavirus in frugivorous Malagasy bats.One health outlook · 2025Article
- Experimental Infection of Egyptian Rousette Bats (Rousettus aegyptiacus) with Marburg Virus.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Review
- Robust evidence for bats as reservoir hosts is lacking in most African virus studies: a review and call to optimize sampling and conserve bats.Biology letters · 2023Review
- Article
- Zaire ebolavirus surveillance near the Bikoro region of the Democratic Republic of the Congo during the 2018 outbreak reveals presence of seropositive bats.PLoS neglected tropical diseases · 2022Article
- Isolation of infectious Lloviu virus from Schreiber's bats in Hungary.Nature communications · 2022Article
- Dynamics of Antibodies to Ebolaviruses in anViruses · 2022Article
- Bats as putative Zaire ebolavirus reservoir hosts and their habitat suitability in Africa.Scientific reports · 2020Article
- Serological Evidence for Henipa-like and Filo-like Viruses in Trinidad Bats.The Journal of infectious diseases · 2020Article
- Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication.The Journal of infectious diseases · 2020Article
- Seroreactive Profiling of Filoviruses in Chinese Bats Reveals Extensive Infection of Diverse Viruses.Journal of virology · 2020Article
- Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa.Nature communications · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the exception of Reston and Bombali viruses, the marburgviruses and ebolaviruses (family Filoviridae) cause outbreaks of viral hemorrhagic fever in sub-Saharan Africa. The Egyptian rousette bat (ERB) is a natural reservoir host for the marburgviruses and evidence suggests that bats are also natural reservoirs for the ebolaviruses. Although the search for the natural reservoirs of the ebolaviruses has largely involved serosurveillance of the bat population, there are no validated serological assays to screen bat sera for ebolavirus-specific IgG antibodies. Here, we generate filovirus-specific antisera by prime-boost immunization of groups of captive ERBs with all seven known culturable filoviruses. After validating a system of filovirus-specific indirect ELISAs utilizing infectious-based virus antigens for detection of virus-specific IgG antibodies from bat sera, we assess the level of serological cross-reactivity between the virus-specific antisera and heterologous filovirus antigens. This data is then used to generate a filovirus antibody fingerprint that can predict which of the filovirus species in the system is most antigenically similar to the species responsible for past infection. Our filovirus IgG indirect ELISA system will be a critical tool for identifying bat species with high ebolavirus seroprevalence rates to target for longitudinal studies aimed at establishing natural reservoir host-ebolavirus relationships.
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