ArticleScientific reports2019
Blocking RpoN reduces virulence of Pseudomonas aeruginosa isolated from cystic fibrosis patients and increases antibiotic sensitivity in a laboratory strain.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Flavonoid-mediated bacterial spermidine biosynthesis enhances vitamin accumulation in tomato fruits.Nature communications · 2026Article
- Article
- Analysis and comparison of the bacterial σ54 regulon: Evidence of phylogenetic trends in gene regulation.PloS one · 2025Article
- The sigma factor σFrontiers in microbiology · 2025Article
- Impact of Nutrient Starvation on Biofilm Formation inAntibiotics (Basel, Switzerland) · 2024Article
- Spread ofAntibiotics (Basel, Switzerland) · 2023Article
- Decoding Genetic Features and Antimicrobial Susceptibility ofInternational journal of molecular sciences · 2022Article
- Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.Microorganisms · 2022Review
- RpoN-Based stapled peptides with improved DNA binding suppressRSC medicinal chemistry · 2022Article
- Characterization of the RpoN regulon reveals the regulation of motility, T6SS2 and metabolism inFrontiers in microbiology · 2022Article
- The Regulatory Functions of σInternational journal of molecular sciences · 2021Review
- Polyclonality, Shared Strains, and Convergent Evolution in Chronic Cystic FibrosisAmerican journal of respiratory and critical care medicine · 2021Article
- Prevalence of the Genes Associated with Biofilm and Toxins Synthesis amongst theAntibiotics (Basel, Switzerland) · 2021Article
- Involvement of RpoN in Regulating Motility, Biofilm, Resistance, and Spoilage Potential ofFrontiers in microbiology · 2021Article
- Potentiation of Aminoglycoside Lethality by CAntimicrobial agents and chemotherapy · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Multidrug-resistant organisms are increasing in healthcare settings, and there are few antimicrobials available to treat infections from these bacteria. Pseudomonas aeruginosa is an opportunistic pathogen in burn patients and individuals with cystic fibrosis (CF), and a leading cause of nosocomial infections. P. aeruginosa is inherently resistant to many antibiotics and can develop resistance to others, limiting treatment options. P. aeruginosa has multiple sigma factors to regulate transcription. The alternative sigma factor, RpoN (σ
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.