Evidence map›Paper›PMID 31040291›Full record

ArticleScientific reports2019

Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane.

David W Barrett, Rebecca K John, Christopher Thrasivoulou, Alvaro Mata, Jan A Deprest, David L Becker, Anna L David, Tina T Chowdhury

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. A Minimalist Model Lipid System Mimicking the Biophysical Properties ofLangmuir : the ACS journal of surfaces and colloids · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

David W BarrettInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Rebecca K JohnInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Christopher ThrasivoulouDepartment of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0001-9425-8624
Alvaro MataInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Jan A DeprestDepartment of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.
David L BeckerLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.
Anna L DavidInstitute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, UK.ORCID http://orcid.org/0000-0002-0199-6140
Tina T ChowdhuryInstitute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. t.t.chowdhury@qmul.ac.uk.
Queen Mary University of London · GBUniversity College London · GBKU Leuven · BENanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical and inflammatory signals in the fetal membrane play an important role in extracellular matrix (ECM) remodelling in order to dictate the timing of birth. We developed a mechanical model that mimics repetitive stretching of the amniotic membrane (AM) isolated from regions over the placenta (PAM) or cervix (CAM) and examined the effect of cyclic tensile strain (CTS) on mediators involved in mechanotransduction (Cx43, AKT), tissue remodelling (GAGs, elastin, collagen) and inflammation (PGE

Indexed as

AmnionCervix UteriCollagenConnexin 43DinoprostoneElastinFemaleGene Expression Regulation, DevelopmentalHumansInflammationMatrix MetalloproteinasesMechanotransduction, CellularPlacentaPregnancyProto-Oncogene Proteins c-aktCollagenConnexin 43DinoprostoneElastinGJA1 protein, humanMatrix MetalloproteinasesProto-Oncogene Proteins c-akt

Identifiers

PMID31040291
PMCPMC6491562
OpenAlexW2943317664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.