ArticleNature communications2019
Red-shifting mutation of light-driven sodium-pump rhodopsin.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 83 citations in OpenAlex.
- Functional Insertion of the Light-Induced Ion Pump KR2 into Block Copolymer Membranes.Biomacromolecules · 2026Article
- Rhobot-Screen: an integrated robotic platform for functional screening of rhodopsin variants.BMC biology · 2026Article
- Priority effects inhibit the repeated evolution of phototrophy.Npj complexity · 2026Article
- Structural and spectroscopic basis of excitation energy transfer in microbial rhodopsins binding xanthophylls.Chemical science · 2025Article
- Article
- Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.bioRxiv : the preprint server for biology · 2025Article
- Rhodopsin charge diffusion computations disclose contrasting color-tuning mechanisms.Nature communications · 2025Article
- Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification.Science advances · 2025Article
- HulaChrimson: A Chrimson-like cation channelrhodopsin discovered using freshwater metatranscriptomics from Lake Hula.Biophysics and physicobiology · 2025Article
- RhoMax: Computational Prediction of Rhodopsin Absorption Maxima Using Geometric Deep Learning.Journal of chemical information and modeling · 2024Article
- Protonation of Asp116 and distortion of the all-trans retinal chromophore in Krokinobacter eikastus rhodopsin 2 causes a redshift in absorption maximum upon dehydration.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Diversity of rhodopsin cyclases in zoospore-forming fungi.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- NaMolecules (Basel, Switzerland) · 2023Review
- Retinal chromophore charge delocalization and confinement explain the extreme photophysics of Neorhodopsin.Nature communications · 2022Article
- Evolution of the Automatic Rhodopsin Modeling (ARM) Protocol.Topics in current chemistry (Cham) · 2022Review
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Pro219 is an electrostatic color determinant in the light-driven sodium pump KR2.Communications biology · 2021Article
- Advances and prospects of rhodopsin-based optogenetics in plant research.Plant physiology · 2021Review
- Crystal structure of schizorhodopsin reveals mechanism of inward proton pumping.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Exploration of natural red-shifted rhodopsins using a machine learning-based Bayesian experimental design.Communications biology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
Abstract
Microbial rhodopsins are photoreceptive membrane proteins that transport various ions using light energy. While they are widely used in optogenetics to optically control neuronal activity, rhodopsins that function with longer-wavelength light are highly demanded because of their low phototoxicity and high tissue penetration. Here, we achieve a 40-nm red-shift in the absorption wavelength of a sodium-pump rhodopsin (KR2) by altering dipole moment of residues around the retinal chromophore (KR2 P219T/S254A) without impairing its ion-transport activity. Structural differences in the chromophore of the red-shifted protein from that of the wildtype are observed by Fourier transform infrared spectroscopy. QM/MM models generated with an automated protocol show that the changes in the electrostatic interaction between protein and chromophore induced by the amino-acid replacements, lowered the energy gap between the ground and the first electronically excited state. Based on these insights, a natural sodium pump with red-shifted absorption is identified from Jannaschia seosinensis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.