ArticleScience signaling2019
Loss of MCU prevents mitochondrial fusion in G
Open access · greenAbstract read
In one paragraph
Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Macrophage-associated kinase signaling in atherosclerosis - a systematic review.Cell communication and signaling : CCS · 2026Pooled it
- Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury.Nature communications · 2025Article
- Mitochondrial Calcium Uniporter Regulates Metabolic Remodeling and Smooth Muscle Cell Proliferation in Type 2 Diabetes.Journal of the American Heart Association · 2025Article
- MIRO1 controls energy production and proliferation of vascular smooth muscle cells.bioRxiv : the preprint server for biology · 2025Article
- Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target.Cancer cell · 2025Article
- Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma.Science advances · 2025Article
- Mitochondria - the CEO of the cell.Journal of cell science · 2025Review
- Article
- MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology.Journal of advanced research · 2025Review
- Impaired endothelial function contributes to cardiac dysfunction: role of mitochondrial dynamics.American journal of physiology. Heart and circulatory physiology · 2025Review
- Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection.Basic research in cardiology · 2024Review
- KRAP regulates mitochondrial Ca2+ uptake by licensing IP3 receptor activity and stabilizing ER-mitochondrial junctions.Journal of cell science · 2024Article
- Yingxiang Acupoint Embedding Improves Mucosal Barrier Function in Rats with Local Allergic Rhinitis.International archives of allergy and immunology · 2024Article
- Regulation of Smooth Muscle Cell Proliferation by Mitochondrial Ca2+ in Type 2 Diabetes.International journal of molecular sciences · 2023Article
- Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.Journal of molecular and cellular cardiology · 2023Article
- The mitochondrial CabioRxiv : the preprint server for biology · 2023Article
- MARS2 drives metabolic switch of non-small-cell lung cancer cells via interaction with MCU.Redox biology · 2023Article
- The mitochondrial regulation of smooth muscle cell proliferation in type 2 diabetes.bioRxiv : the preprint server for biology · 2023Article
- Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2.Antioxidants (Basel, Switzerland) · 2023Article
- The mitochondrial CaFrontiers in cell and developmental biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Olha M KovalAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-1644-0046
Emily K NguyenAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Velarchana SanthanaAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Trevor P FidlerFraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-0758-9984
Sara C SebagAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Tyler P RasmussenAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-8922-6521
Dylan J MittauerAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Stefan StrackDepartment of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-6175-7280
Prabhat C GoswamiFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.
E Dale AbelAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-5290-0738
Isabella M GrumbachAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. isabella-grumbach@uiowa.edu.ORCID 0000-0002-2285-3157
University of Iowa · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MNRSA Training CoreTL1TR001875 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPANN, MARISA N, TAYLOR, JACQUELYN Y · 2016 to 2025
$8.9MMitochondrial CaMKII drives smooth muscle migration and neointimal hyperplasiaR01HL108932 · NHLBI · UNIVERSITY OF IOWA · PI GRUMBACH, ISABELLA MARIA · 2012 to 2021
$3.6MInsulin Inhibition of beta-AR Signaling in the MyocardiumR01HL127764 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$2.4MTargeting Mitochondrial Fission for Neuroprotection in Diabetic NeuropathyR01DK116624 · NIDDK · UNIVERSITY OF IOWA · PI STRACK, STEFAN, USACHEV, YURIY M · 2018 to 2021
$2.1MRedox Biology of Quiescent Normal Fibroblasts and Epithelial Cancer ProgressionR01CA111365 · NCI · UNIVERSITY OF IOWA · PI GOSWAMI, PRABHAT C · 2006 to 2016
$2.1MCardiac Dysfunction in the Met Syndrome: Cross-talk between IR and bAR SignalingR01HL112413 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$1.6MThe role of mitochondrial CaMKII in diabetic vascular restenosisF30HL131078 · NHLBI · UNIVERSITY OF IOWA · PI NGUYEN, EMILY KIM · 2016 to 2019
$106kMitochondrial CAMKII in smooth muscle as key regulator of hypertension and vascular remodelingI01BX000163 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI Isabella Maria Grumbach · 2011 to 2026
–BLRD VA I01 BX000163NCATS NIH HHS TL1 TR001875NCI NIH HHS R01 CA111365NHLBI NIH HHS F30 HL131078NHLBI NIH HHS R01 HL108932NHLBI NIH HHS R01 HL112413NHLBI NIH HHS R01 HL127764NIDDK NIH HHS R01 DK116624NIGMS NIH HHS T32 GM007337
Abstract
The role of the mitochondrial Ca
Indexed as
AnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium ChannelsCell ProliferationCells, CulturedDynaminsFemaleG1 Phase Cell Cycle CheckpointsMaleMice, KnockoutMitochondrial DynamicsMuscle, Smooth, VascularMyocytes, Smooth MusclePhosphorylationCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium ChannelsDnm1l protein, mouseDynaminsmitochondrial calcium uniporter
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.