Evidence map›Paper›PMID 31040258›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Phototransduction gain at the G-protein, transducin, and effector protein, phosphodiesterase-6, stages in retinal rods.

Martin Heck, Klaus Peter Hofmann, Timothy W Kraft, Trevor D Lamb

Open access · bronzeAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. New focus on regulation of the rod photoreceptor phosphodiesterase.Current opinion in structural biology · 2021
    Review
  4. Article
  5. Article
  6. Reply to Heck et al.: Signal amplification at the rhodopsin-to-transducin·phosphodiesterase step in rod phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Martin HeckInstitut für Medizinische Physik und Biophysik der Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10117 Berlin, Germany.
Klaus Peter HofmannInstitut für Medizinische Physik und Biophysik der Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10117 Berlin, Germany.
Timothy W KraftDepartment of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, AL 35294; twkraft@uab.edu.
Trevor D LambEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, Australia.ORCID 0000-0003-0299-6115
Humboldt-Universität zu Berlin · DEAustralian National University · AUUniversity of Alabama at Birmingham · US

Funding

Short Term Adaptations in PhotoreceptorsR01EY023603 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRAFT, TIMOTHY W, SINCICH, LAWRENCE C · 2014 to 2022
$3.1M
NEI NIH HHS R01 EY023603
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cyclic Nucleotide Phosphodiesterases, Type 6TransducinGTP-Binding ProteinsLight Signal TransductionRetinal Rod Photoreceptor CellsCyclic Nucleotide Phosphodiesterases, Type 6GTP-Binding ProteinsTransducin

Identifiers

PMID31040258
PMCPMC6500165
OpenAlexW2943596587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.