Evidence map›Paper›PMID 31040237›Full record

ArticlemBio2019

Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation.

Jennifer Martynowicz, Leonardo Augusto, Ronald C Wek, Stephen L Boehm, William J Sullivan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. Article
  3. iScience · 2026
    Article
  4. Article
  5. Life (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Review
  8. Approaches for TargetingPathogens (Basel, Switzerland) · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. From the immune system to mood disorders especially induced byFrontiers in cellular and infection microbiology · 2023
    Review
  16. A Review of the Biological Activity of Amidrazone Derivatives.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  17. Article
  18. The determinants regulatingFrontiers in microbiology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jennifer MartynowiczDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Leonardo AugustoDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ronald C WekDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Stephen L BoehmDepartment of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA.
William J SullivanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA wjsulliv@iu.edu.ORCID 0000-0003-1823-8642
Indiana University School of MedicineUniversity of Indianapolis · US

Funding

Immunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0M
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
Translational control during stage conversion of Toxoplasma, an opportunistic infection of HIV/AIDSR01AI124723 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI SULLIVAN, WILLIAM J, WEK, RONALD C · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI124723NIAID NIH HHS T32 AI060519NIGMS NIH HHS T32 GM077229
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntiprotozoal AgentsBrainDisease Models, AnimalFemaleGuanabenzHyperkinesisInflammationMaleMiceMice, Inbred BALB CMice, Inbred C57BLToxoplasmosis, CerebralTreatment OutcomeAntiprotozoal AgentsGuanabenzbehavior modificationguanabenzhost-pathogen interactionsneuroinflammationparasitesToxoplasma

Identifiers

PMID31040237
PMCPMC6495372
OpenAlexW2942801502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.