SynthesismBio2019
Meta-analysis of Plasmodium falciparum
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Clinical Spectrum and Admission Correlates of Complicated Imported Malaria in Polish Travellers: An 11-Year Retrospective Analysis with Geographic Mapping of Travel Destinations.Journal of clinical medicine · 2026Article
- Competitive resource allocation drives asynchronous and rapid nuclear multiplication in the malaria parasite.Nature communications · 2026Article
- Genotypic and antigenic diversity of Plasmodium falciparum merozoite proteins in Malawian children with severe and uncomplicated malaria.Malaria journal · 2025Article
- Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model.Nature communications · 2025Article
- Cerebral manifestations of falciparum malaria in adults: more than meets the eye.Trends in parasitology · 2025Review
- Evasive mechanisms of human VSG and PfEMP1 antigens with link to Vaccine scenario: a review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Breaking the bind: PfEMP1-specific antibodies in cerebral malaria.Frontiers in immunology · 2025Review
- The malarial blood transcriptome: translational applications.Biochemical Society transactions · 2024Review
- Broadly inhibitory antibodies against severe malaria virulence proteins.bioRxiv : the preprint server for biology · 2024Article
- PfEMP1 and var genes - Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity.Advances in parasitology · 2024Review
- Pathogenetic mechanisms and treatment targets in cerebral malaria.Nature reviews. Neurology · 2023Review
- Different PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during co-culture.PloS one · 2023Article
- Diagnosis of cerebral malaria: Tools to reduceFrontiers in cellular and infection microbiology · 2023Review
- Article
- The spectrum of clinical biomarkers in severe malaria and new avenues for exploration.Virulence · 2022Review
- CD36-A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection.Microorganisms · 2022Review
- Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India.The American journal of tropical medicine and hygiene · 2022Article
- Controlled human malaria infections by mosquito bites induce more severe clinical symptoms than asexual blood-stage challenge infections.EBioMedicine · 2022Article
- Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1.Infection and immunity · 2022Article
- Determinants of brain swelling in pediatric and adult cerebral malaria.JCI insight · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 9 institutions in 7 countries.
Fergal Duffy *Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-4675-0937
Maria Bernabeu *Seattle Children's Research Institute, Seattle, Washington, USA.
Prasad H BabarGoa Medical College & Hospital, Bambolim, Goa, India.
Anne KesslerAlbert Einstein College of Medicine, Bronx, New York, USA.
Christian W WangCentre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Marina VazGoa Medical College & Hospital, Bambolim, Goa, India.
Laura CheryDepartments of Chemistry and Global Health, University of Washington, Seattle, Washington, USA.
Wilson L MandalaMalawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Stephen J RogersonDepartment of Medicine at the Doherty Institute, The University of Melbourne, Melbourne, Australia.
Terrie E TaylorBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Karl B SeydelBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Thomas LavstsenCentre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3044-4249
Edwin GomesGoa Medical College & Hospital, Bambolim, Goa, India.
Kami KimAlbert Einstein College of Medicine, Bronx, New York, USA.
John LusinguCentre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Pradipsinh K RathodDepartments of Chemistry and Global Health, University of Washington, Seattle, Washington, USA.
John D AitchisonSeattle Children's Research Institute, Seattle, Washington, USA john.aitchison@seattlechildrens.org joe.smith@seattlechildrens.org.
Joseph D SmithSeattle Children's Research Institute, Seattle, Washington, USA john.aitchison@seattlechildrens.org joe.smith@seattlechildrens.org.
University of Copenhagen · DKUniversity of Washington · USAlbert Einstein College of Medicine · USGoa Medical College · INUniversity of Malawi · MWInstitute for Systems Biology · USSeattle Children's Hospital · USThe University of Melbourne · AUUniversity of Liverpool · GB
Funding
CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7MShared TechnologyU19AI089688 · NIAID · UNIVERSITY OF WASHINGTON · PI RATHOD, PRADIPSINH K. · 2010 to 2023
$22.4MTR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8MCLINICOPATHOLOGICAL CORRELATES OF CEREBRAL MALARIAR01AI034969 · NIAID · MICHIGAN STATE UNIVERSITY · PI TAYLOR, TERRIE ELLEN · 1996 to 2011
$3.2MClinical and Translational Science AwardTL1TR001072 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHAMOON, HARRY · 2013 to 2017
$909kNCATS NIH HHS TL1 TR001072NCATS NIH HHS UL1 TR002556NIAID NIH HHS R01 AI034969NIAID NIH HHS U19 AI089688NIGMS NIH HHS P41 GM109824
Abstract
The clinical presentation of severe
Indexed as
Genetic VariationGenotypeAdultChildChild, PreschoolCohort StudiesFemaleHumansIndiaInfantMachine LearningMalaria, FalciparumMalawiMaleParasite LoadPlasmodium falciparumerythrocyte membrane protein 1, Plasmodium falciparumProtozoan Proteinscerebral malariamachine learningmalariaPfEMP1Plasmodium falciparumsevere malariavar gene
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.