ArticleBioscience reports2019
Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage.
Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Aging and age-related diseases with a focus on therapeutic potentials of young blood/plasma.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation.Theranostics · 2024Article
- Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Heterochronic Plasma Transfer: Experimental Design, Considerations, and Technical Challenges.Rejuvenation research · 2023Review
- Sterile inflammation in liver transplantation.Frontiers in medicine · 2023Review
- The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies.International journal of molecular sciences · 2022Review
- Intracerebral Hemorrhage: The Effects of Aging on Brain Injury.Frontiers in aging neuroscience · 2022Review
- Redistribution of Histone Marks on Inflammatory Genes Associated With Intracerebral Hemorrhage-Induced Acute Brain Injury in Aging Rats.Frontiers in neuroscience · 2022Article
- TMT-based quantitative proteomic analysis reveals defense mechanism of wheat against the crown rot pathogen Fusarium pseudograminearum.BMC plant biology · 2021Article
- Young plasma attenuates cognitive impairment and the cortical hemorrhage area in cerebral amyloid angiopathy model mice.Annals of translational medicine · 2021Article
- Age-related CCL12 Aggravates Intracerebral Hemorrhage-induced Brain Injury via Recruitment of Macrophages and T Lymphocytes.Aging and disease · 2020Article
- Cold-inducible RNA-binding protein contributes to intracerebral hemorrhage-induced brain injury via TLR4 signaling.Brain and behavior · 2020Article
- Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice.International journal of molecular sciences · 2020Article
- Age-Dependent Changes in the Plasma Proteome of Healthy Adults.The journal of nutrition, health & aging · 2020Article
- Quantitative Profiling of Oxylipins in Acute Experimental Intracerebral Hemorrhage.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging has been shown to contribute to both the declined biofunctions of aging brain and aggravation of acute brain damage, and the former could be reversed by young plasma. These results suggest that young plasma treatment may also reduce the acute brain damage induced by intracerebral hemorrhage (ICH). In the present study, we first found that the administration of young plasma significantly reduced the mortality and neurological deficit score in aging ICH rodents, which might be due to the decreased brain water content, damaged neural cells, and increased survival neurons around the perihematomal brain tissues. Then, proteomics analysis was used to screen out the potential neuroprotective circulating factors and the results showed that many factors were changed in health human plasma among young, adult, and old population. Among these significantly changed factors, the plasma insulin-like growth factor 1 (IGF-1) level was significantly decreased with age, which was further confirmed both in human and rats detected by ELISA. Additionally, the brain IGF-1 protein level in aging ICH rats was markedly decreased when compared with young rats. Interestingly, the relative decreased brain IGF-1 level was reversed by the treatment of young plasma in aging ICH rats, while the mRNA level was non-significantly changed. Furthermore, the IGF-1 administration significantly ameliorated the acute brain injury in aging ICH rats. These results indicated that young circulating factors, like IGF-1, may enter brain tissues to exert neuroprotective effects, and young plasma may be considered as a novel therapeutic approach for the clinical treatment of aging-related acute brain injury.
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