ArticleScandinavian journal of trauma, resuscitation and emergency medicine2019
Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 194 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Recognition and Dynamic Risk Warning System of Multiple Organ Dysfunction Syndrome Caused by Sepsis
An Observational Pilot Study for the Multi-Modality Risk Prediction and Early Identification of Critically Ill Septic Patients in the Emergency Department
The Effect of Extracorporeal Sepsis Adsorption Column Use on Plasma Syndecan-1 Level and Mortality in Sepsis Patients
Who cites it
194 citing papers in PubMed, 6 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- Lactate-enhanced-qSOFA (LqSOFA) score as a predictor of in-hospital mortality in patients with sepsis: systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Pooled it
- Machine learning-based mortality risk prediction models in patients with sepsis-associated acute kidney injury: a systematic review.Frontiers in medicine · 2025Pooled it
- Predictive value of the neutrophil-to-lymphocyte ratio in the prognosis and risk of death for adult sepsis patients: a meta-analysis.Frontiers in immunology · 2024Pooled it
- Machine learning for the prediction of sepsis-related death: a systematic review and meta-analysis.BMC medical informatics and decision making · 2023Pooled it
- Pooled it
- Evaluate prognostic accuracy of SOFA component score for mortality among adults with sepsis by machine learning method.BMC infectious diseases · 2023Trial
- Establishment of a prognostic model for patients with sepsis based on SOFA: a retrospective cohort study.The Journal of international medical research · 2021Trial
- METTL7B Expression in Sepsis: Association With Disease Severity and 28-Day Mortality.Journal of clinical laboratory analysis · 2026Article
- Day-7 lactate-to-albumin ratio as a prognostic marker in sepsis patients requiring prolonged mechanical ventilation: a multicenter retrospective landmark analysis of the Korean Sepsis Alliance registry.Journal of thoracic disease · 2026Article
- Prognostic value of the lactate-based modified cally score in postoperative gastric cancer patients admitted to the ICU.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Machine Learning-Augmented Traditional Analysis of Lactate vs Lactate-to-Albumin Ratio for Predicting Mortality Risk in Patients With Sepsis: Large-Scale Retrospective Study.JMIR medical informatics · 2026Observational
- Improved 28-day mortality prediction by combining Lactate Dehydrogenase-to-Albumin Ratio(LAR) to lactate-enhanced Sequential Organ Failure Assessment (SOFA) score in patients with sepsis: a derivation and validation study.BMC infectious diseases · 2026Article
- Sepsis in critically ill dogs: identification of clinical and laboratory risk factors and evaluation of sepsis scoring systems.Journal of veterinary internal medicine · 2026Article
- Integrating host mRNA signatures and clinical trajectories with machine learning for risk stratification and survival prediction in sepsis: an ICU-based prospective cohort study.BMC infectious diseases · 2026Article
- Sepsis prognosis in the emergency department: assessment of shock indices, SOFA, qSOFA, and lactate.International journal of emergency medicine · 2026Article
- An interpretable machine-learning model for post-admission reassessment of bloodstream infection risk in ICU patients with pneumonia.Scientific reports · 2026Article
- Development and external validation of the HCH and HPMS prognostic indices for sepsis: a retrospective model development study using a Multi-Objective Non-Newtonian Fluid optimization algorithm.BMC medical informatics and decision making · 2026Article
- Predictive validity of daily sequential organ failure assessment (SOFA)-2 score for 30-day mortality.Critical care (London, England) · 2026Observational
- Prognostic determinants of mortality and clinical outcomes in sepsis: a retrospective cohort study.BMC infectious diseases · 2026Article
134 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSepsis is a common critical condition caused by the body's overwhelming response to certain infective agents. Many biomarkers, including the serum lactate level, have been used for sepsis diagnosis and guiding treatment. Recently, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) recommended the Sequential Organ Failure Assessment (SOFA) and the quick SOFA (qSOFA) rather than lactate for screening sepsis and assess prognosis. Here, we aim to explore and compare the prognostic accuracy of the lactate level, the SOFA score and the qSOFA score for mortality in septic patients using the public Medical Information Mart for Intensive Care III database (MIMIC III).
methodsThe baseline characteristics, laboratory test results and outcomes for sepsis patients were retrieved from MIMIC III. Survival was analysed by the Kaplan-Meier method. Univariate and multivariate analysis was performed to identify predictors of prognosis. Receiver operating characteristic curve (ROC) analysis was conducted to compare lactate with SOFA and qSOFA scores.
resultsA total of 3713 cases were initially identified. The analysis cohort included 1865 patients. The 24-h average lactate levels and the worst scores during the first 24 h of ICU admission were collected. Patients in the higher lactate group had higher mortality than those in the lower lactate group. Lactate was an independent predictor of sepsis prognosis. The AUROC of lactate (AUROC, 0.664 [95% CI, 0.639-0.689]) was significantly higher than that of qSOFA (AUROC, 0.547 [95% CI, 0.521-0.574]), and it was similar to the AUROC of SOFA (AUROC, 0.686 [95% CI, 0.661-0.710]). But the timing of lactate relative to SOFA and qSOFA scores was inconsistent.
conclusionLactate is an independent prognostic predictor of mortality for patients with sepsis. It has superior discriminative power to qSOFA, and shows discriminative ability similar to that of SOFA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.