ArticleCardiovascular diabetology2019
Myocardial mechano-energetic efficiency and insulin resistance in non-diabetic members of the Strong Heart Study cohort.
Article in Cardiovascular diabetology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005134 (Strong Heart Study), which is not on this map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strong Heart Study
Who cites it
50 citing papers in PubMed, 87 citations in OpenAlex.
- Association of Triglyceride-Glucose Index With Different Cardiovascular Diseases in Non-Diabetic Hypertension.Journal of cellular and molecular medicine · 2025Trial
- Coronary flow reserve increase after 4-year dapagliflozin treatment in patients with type 2 diabetes: the DAPAHEART follow-up study.Cardiovascular diabetology · 2025Trial
- Effects of 26 weeks of treatment with empagliflozin versus glimepiride on the myocardial glucose metabolic rate in patients with type 2 diabetes: The randomized, open-label, crossover, active-comparator FIORE trial.Diabetes, obesity & metabolism · 2022Trial
- Association of the triglyceride-glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus: mediation by myocardial energetic efficiency and resting perfusion.Cardiovascular diabetology · 2026Article
- Myocardial oxygen consumption, myocardial efficiency, and mechanical efficiency: A review across pathologic and physiologic states.Physiological reports · 2026Review
- Prognostic value of the triglyceride-glucose index in patients with acute ischemic stroke undergoing endovascular treatment.The Journal of international medical research · 2026Article
- The Triglyceride-Glucose Index: A Novel Marker for Clinical Atherosclerotic Cardiovascular Disease Risk Stratification.Annals of African medicine · 2026Review
- Association between the newly proposed triglyceride glucose-a body shape index (TyG-ABSI) and atherosclerotic cardiovascular disease in the general population: modest diagnostic improvement compared with traditional TyG-related parameters.Cardiovascular diabetology · 2026Article
- Impact of TyG index on coronary plaques in patients with coronary artery disease under aggressive lipid-lowering therapy.Frontiers in endocrinology · 2026Observational
- Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Triglyceride glucose-waist circumference dynamics and cardiovascular risk: a national longitudinal study.Lipids in health and disease · 2025Article
- Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction.Cardiovascular diabetology · 2025Article
- A decline in renal function is associated with a reduction in myocardial mechano-energetic efficiency in individuals at high cardiometabolic risk.Cardiovascular diabetology · 2025Article
- The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study.Cardiovascular diabetology · 2025Article
- Association between the cardiometabolic index and all-cause and cardiovascular mortality in diabetes and prediabetes.Cardiovascular diagnosis and therapy · 2025Article
- The triglyceride glucose (TyG) index is associated with decreased myocardial mechano-energetic efficiency in individuals with different glucose tolerance status.European journal of clinical investigation · 2025Article
- Relationship between hemoglobin glycation index and myocardial mechano-energetic efficiency in non-diabetic individual.Cardiovascular diabetology · 2025Article
- Article
- Associations of the triglyceride-glucose index and remnant cholesterol levels with the prevalence of Carotid Plaque in patients with type 2 diabetes: a retrospective study.Lipids in health and disease · 2025Article
- Opposite outcomes of triglyceride-glucose index and associated cardiovascular mortality risk in type 2 diabetes mellitus participants by different obesity criteria.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMyocardial energetic efficiency (MEE), is a strong predictor of CV events in hypertensive patient and is reduced in patients with diabetes and metabolic syndrome. We hypothesized that severity of insulin resistance (by HOMA-IR) negatively influences MEE in participants from the Strong Heart Study (SHS).
methodsWe selected non-diabetic participants (n = 3128, 47 ± 17 years, 1807 women, 1447 obese, 870 hypertensive) free of cardiovascular (CV) disease, by merging two cohorts (Strong Heart Study and Strong Heart Family Study, age range 18-93). MEE was estimated as stroke work (SW = systolic blood pressure [SBP] × stroke volume [SV])/"double product" of SBP × heart rate (HR), as an estimate of O
resultsLinear trend analyses showed that with increasing quartiles of HOMA-IR patients were older, more likely to be women, obese and hypertensive, with a trend toward a worse lipid profile (all p for trend < 0.001), progressive increase in LV mass index, stroke index and cardiac index and decline of wall mechanics (all p < 0.0001). In multivariable regression, after adjusting for confounders, and including a kinship coefficient to correct for relatedness, MEEi was negatively associated with HOMA-IR, independently of significant associations with age, sex, blood pressure, lipid profile and central obesity (all p < 0.0001).
conclusionsSeverity of insulin resistance has significant and independent negative impact on myocardial mechano-energetic efficiency in nondiabetic individual from a population study of American Indians. Trial registration number NCT00005134, Name of registry: Strong Heart Study, URL of registry: https://clinicaltrials.gov/ct2/show/NCT00005134 , Date of registration: May 25, 2000, Date of enrolment of the first participant to the trial: September 1988.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.