ArticleBMC infectious diseases2019
Understanding the spatial distribution of trichiasis and its association with trachomatous inflammation-follicular.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Community-level trachoma ecological associations and the use of geospatial analysis methods: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Using Model-Based Geostatistics to Refine Population-Based Estimates of Trachoma Prevalence: Update from a Technical Consultation.The American journal of tropical medicine and hygiene · 2025Article
- Global, Regional, and National Burden of Trachoma: Cross-Country Inequalities, 1990-2021, with Projections to 2040.Ophthalmology and therapy · 2025Article
- Severity of Trachomatous Scarring among Adults in Trachoma-Endemic Amhara Region of Ethiopia.The American journal of tropical medicine and hygiene · 2024Article
- Expression activation of over 70% ofInfection and immunity · 2024Article
- Prevalence of Trachoma from 66 Impact Surveys in 52 Woredas of Southern Nations, Nationalities and Peoples' and Sidama Regions of Ethiopia, 2017-2019.Ophthalmic epidemiology · 2023Article
- Neglected tropical diseases in Republic of Guinea: disease endemicity, case burden and the road towards the 2030 target.International health · 2023Review
- Changes in trachoma indicators in Kiribati with two rounds of azithromycin mass drug administration, measured in serial population-based surveys.PLoS neglected tropical diseases · 2023Article
- Perceptions of ophthalmologists on the impact of trachoma in Egypt: a mixed-methods, nationwide survey.BMC infectious diseases · 2023Article
- Epidemiology and control of trachoma in the state of Ceará, Northeast Brazil, 2007-2021.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Trachoma.Nature reviews. Disease primers · 2022Review
- Spatial scales in human movement between reservoirs of infection.Journal of theoretical biology · 2021Article
- Insights from mathematical modelling and quantitative analysis on the proposed 2030 goals for trachoma.Gates open research · 2019Article
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Authors and funding
28 authors.
Funding
Abstract
backgroundWhilst previous work has identified clustering of the active trachoma sign "trachomatous inflammation-follicular" (TF), there is limited understanding of the spatial structure of trachomatous trichiasis (TT), the rarer, end-stage, blinding form of disease. Here we use community-level TF prevalence, information on access to water and sanitation, and large-scale environmental and socio-economic indicators to model the spatial variation in community-level TT prevalence in Benin, Cote d'Ivoire, DRC, Guinea, Ethiopia, Malawi, Mozambique, Nigeria, Sudan and Uganda.
methodsWe fit binomial mixed models, with community-level random effects, separately for each country. In countries where spatial correlation was detected through a semi-variogram diagnostic check we then fitted a geostatistical model to the TT prevalence data including TF prevalence as an explanatory variable.
resultsThe estimated regression relationship between community-level TF and TT was significant in eight countries. We estimate that a 10% increase in community-level TF prevalence leads to an increase in the odds for TT ranging from 20 to 86% when accounting for additional covariates.
conclusionWe find evidence of an association between TF and TT in some parts of Africa. However, our results also suggest the presence of additional, country-specific, spatial risk factors which modulate the variation in TT risk.
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