ArticleProceedings. Biological sciences2019
Dietary macronutrient content, age-specific mortality and lifespan.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification.Aging cell · 2023Trial
- Macronutrient mixtures and interactions in health and disease.Nature reviews. Endocrinology · 2026Review
- Dietary restriction in aging and longevity.Nature aging · 2026Review
- Associations between national plant-based vs animal-based protein supplies and age-specific mortality in human populations.Nature communications · 2025Article
- eNODAL: an experimentally guided nutriomics data clustering method to unravel complex drug-diet interactions.Briefings in bioinformatics · 2024Article
- Does diet influence aging? Evidence from animal studies.Journal of internal medicine · 2024Review
- Prospective study of protein intake and mortality among US adults with chronic obstructive pulmonary disease.Frontiers in nutrition · 2024Article
- Carbon Dioxide (CONutrients · 2023Article
- Associations between protein to non-protein ratio and intakes of other dietary components in a cohort aged 65-75 years: the Nutrition for Healthy Living Study.Public health nutrition · 2023Article
- Relationships among Development, Growth, Body Size, Reproduction, Aging, and Longevity - Trade-Offs and Pace-Of-Life.Biochemistry. Biokhimiia · 2023Review
- Diet and mitonuclear haplotype interactions affect growth rate in a slime mould.Ecology and evolution · 2023Article
- Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age.GeroScience · 2023Article
- Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice.Nature communications · 2023Article
- Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity.Nature communications · 2023Article
- Macronutrient (im)balance drives energy intake in an obesogenic food environment: An ecological analysis.Obesity (Silver Spring, Md.) · 2022Article
- Diet Composition, Anthropometrics, and Mortality Risk.International journal of environmental research and public health · 2022Article
- Multidimensional associations between nutrient intake and healthy ageing in humans.BMC biology · 2022Article
- Review
- Review
- Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction.Cell metabolism · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein and calorie restrictions extend median lifespan in many organisms. However, studies suggest that among-individual variation in the age at death is also affected. Ultimately, both of these outcomes must be caused by effects of nutrition on underlying patterns of age-specific mortality (ASM). Using model life tables, we tested for effects of dietary macronutrients on ASM in mice ( Mus musculus). High concentrations of protein and fat relative to carbohydrates were associated with low life expectancy and high variation in the age at death, a result caused predominantly by high mortality prior to middle age. A lifelong diet comprising the ratio of macronutrients self-selected by mouse (in early adulthood) was associated with low mortality up until middle age, but higher late-life mortality. This pattern results in reasonably high life expectancy, but very low variation in the age at death. Our analyses also indicate that it may be possible to minimize ASM across life by altering the ratio of dietary protein to carbohydrate in the approach to old age. Mortality in early and middle life was minimized at around one-part protein to two-parts carbohydrate, whereas in later life slightly greater than equal parts protein to carbohydrate reduced mortality.
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Registered trials
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