Evidence map›Paper›PMID 31039696›Full record

Trial reportJournal of the Royal Society, Interface2019

In vivo effects of different orthodontic loading on root resorption and correlation with mechanobiological stimulus in periodontal ligament.

Jingxiao Zhong, Junning Chen, Richard Weinkamer, M Ali Darendeliler, Michael V Swain, Andrian Sue, Keke Zheng, Qing Li

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Methylphenidate-effects on orthodontic tooth movement, orthodontically induced and nonorthodontic root resorption? : A micro-computed tomography and immunohistochemical analysis.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Assessment of the Maximum Amount of Orthodontic Force for PDL in Intact and Reduced Periodontium (Part I).International journal of environmental research and public health · 2023
    Article
  18. Article
  19. The effects of different types of periodontal ligament material models on stresses computed using finite element models.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jingxiao Zhong1 School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney , Sydney , Australia.
Junning Chen2 College of Engineering, Mathematics and Physical Sciences, University of Exeter , Exeter , UK.
Richard Weinkamer3 Department of Biomaterials, Max Planck Institute of Colloids and Interfaces , Potsdam , Germany.
M Ali Darendeliler4 Faculty of Dentistry, Discipline of Orthodontics, University of Sydney , Sydney , Australia.
Michael V Swain1 School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney , Sydney , Australia.
Andrian Sue1 School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney , Sydney , Australia.
Keke Zheng1 School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney , Sydney , Australia.
Qing Li1 School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney , Sydney , Australia.
The University of Sydney · AUMax Planck Institute of Colloids and Interfaces · DEUniversity of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orthodontic root resorption is a common side effect of orthodontic therapy. It has been shown that high hydrostatic pressure in the periodontal ligament (PDL) generated by orthodontic forces will trigger recruitment of odontoclasts, leaving resorption craters on root surfaces. The patterns of resorption craters are the traces of odontoclast activity. This study aimed to investigate resorptive patterns by: (i) quantifying spatial root resorption under two different levels of in vivo orthodontic loadings using microCT imaging techniques and (ii) correlating the spatial distribution pattern of resorption craters with the induced mechanobiological stimulus field in PDL through nonlinear finite-element analysis (FEA) in silico. Results indicated that the heavy force led to a larger total resorption volume than the light force, mainly by presenting greater individual crater volumes ( p < 0.001) than increasing crater numbers, suggesting that increased mechano-stimulus predominantly boosted cellular resorption activity rather than recruiting more odontoclasts. Furthermore, buccal-cervical and lingual-apical regions in both groups were found to have significantly larger resorption volumes than other regions ( p < 0.005). These clinical observations are complemented by the FEA results, suggesting that root resorption was more likely to occur when the volume average compressive hydrostatic pressure exceeded the capillary blood pressure (4.7 kPa).

Indexed as

Compressive StrengthModels, BiologicalPeriodontal LigamentRoot ResorptionX-Ray MicrotomographyFinite Element AnalysisHumansPressuremechano-stimulusnonlinear finite-element analysisodontoclastic activityorthodontic root resorptionperiodontal ligament

Identifiers

PMID31039696
PMCPMC6544889
OpenAlexW2774954132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.