ArticleJournal of the Royal Society, Interface2019
Microstructure-based numerical simulation of the mechanical behaviour of ocular tissue.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Biomechanical Characterization of Central Corneal Region Using Inflation Test and its Application to Predicting Central Corneal Response Under Intraocular Pressure.Annals of biomedical engineering · 2026Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- [Anisotropy and viscoelasticity of different corneal regions in rabbit corneal ectasia model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Novel Multivariable Evolutionary Algorithm-Based Method for Modal Reconstruction of the Corneal Surface from Sparse and Incomplete Point Clouds.Bioengineering (Basel, Switzerland) · 2023Article
- A direct fiber approach to model sclera collagen architecture and biomechanics.Experimental eye research · 2023Article
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Article
- Computational Modeling of Ophthalmic Procedures: Computational Modeling of Ophthalmic Procedures.American journal of ophthalmology · 2022Article
- Biomechanical analysis of ocular diseases and its in vitro study methods.Biomedical engineering online · 2022Review
- Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance.Eye (London, England) · 2021Review
- Fibril density reduction in keratoconic corneas.Journal of the Royal Society, Interface · 2021Article
- Compressive behaviour of soft contact lenses and its effect on refractive power on the eye and handling off the eye.PloS one · 2021Article
- Role of radially aligned scleral collagen fibers in optic nerve head biomechanics.Experimental eye research · 2020Article
- Collagen fiber interweaving is central to sclera stiffness.Acta biomaterialia · 2020Article
- Experimental evaluation of stiffening effect induced by UVA/Riboflavin corneal cross-linking using intact porcine eye globes.PloS one · 2020Article
- Scleral structure and biomechanics.Progress in retinal and eye research · 2020Review
- A Mesh-Free Approach to Incorporate Complex Anisotropic and Heterogeneous Material Properties into Eye-Specific Finite Element Models.Computer methods in applied mechanics and engineering · 2020Article
- Numerical Simulation of Corneal Fibril Reorientation in Response to External Loading.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper aims to present a novel full-eye biomechanical material model that incorporates the characteristics of ocular tissues at microstructural level, and use the model to analyse the age-related stiffening in tissue behaviour. The collagen content in ocular tissues, as obtained using X-ray scattering measurements, was represented by sets of Zernike polynomials that covered both the cornea and sclera, then used to reconstruct maps of collagen fibril magnitude and orientation on the three-dimensional geometry of the eye globe. Fine-mesh finite-element (FE) models with eye-specific geometry were built and supported by a user-defined material model (UMAT), which considered the regional variation of fibril density and orientation. The models were then used in an iterative inverse modelling study to derive the material parameters that represent the experimental behaviour of ocular tissues from donors aged between 50 and 90 years obtained in earlier ex vivo studies. Sensitivity analysis showed that reducing the number of directions that represented the anisotropy of collagen fibril orientation at each X-ray scattering measurement point from 180 to 16 would have limited and insignificant effect on the FE solution (0.08%). Inverse analysis resulted in material parameters that provided a close match with experimental intraocular pressure-deformation behaviour with a root mean square of error between 3.6% and 4.3%. The results also demonstrated a steady increase in mechanical stiffness in all ocular regions with age. A constitutive material model based on distributions of collagen fibril density and orientation has been developed to enable the accurate representation of the biomechanical behaviour of ocular tissues. The model offers a high level of control of stiffness and anisotropy across ocular globe, and therefore has the potential for use in planning surgical and medical procedures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.