Evidence map›Paper›PMID 31039659›Full record

ArticleJournal of the American Heart Association2019

Defective Renal Angiotensin III and AT

Brandon A Kemp, Nancy L Howell, Susanna R Keller, John J Gildea, Weijian Shao, Luis Gabriel Navar, Robert M Carey

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Oxidative Stress in Kidney Injury and Hypertension.Antioxidants (Basel, Switzerland) · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. The Angiotensin ATPharmacological reviews · 2022
    Review
  10. Article
  11. Angiotensin II and ATInternational journal of molecular sciences · 2022
    Review
  12. Review
  13. Renal ATCirculation research · 2022
    Article
  14. Review
  15. Role of the central renin‑angiotensin system in hypertension (Review).International journal of molecular medicine · 2021
    Review
  16. The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2021
    Article
  17. Identification of a Primary Renal ATCirculation research · 2020
    Article
  18. Defective Renal Angiotensin III and ATJournal of the American Heart Association · 2019
    Article
  19. Angiotensin III/ATJournal of the American Heart Association · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Brandon A Kemp1 Division of Endocrinology and Metabolism Department of Medicine University of Virginia School of Medicine Charlottesville VA.
Nancy L Howell1 Division of Endocrinology and Metabolism Department of Medicine University of Virginia School of Medicine Charlottesville VA.
Susanna R Keller1 Division of Endocrinology and Metabolism Department of Medicine University of Virginia School of Medicine Charlottesville VA.
John J Gildea2 Department of Pathology University of Virginia School of Medicine Charlottesville VA.
Weijian Shao3 Department of Physiology and Hypertension and Renal Center Tulane University School of Medicine New Orleans LA.
Luis Gabriel Navar3 Department of Physiology and Hypertension and Renal Center Tulane University School of Medicine New Orleans LA.
Robert M Carey1 Division of Endocrinology and Metabolism Department of Medicine University of Virginia School of Medicine Charlottesville VA.
University of Virginia · USTulane University · US

Funding

Renal AT2 Receptors in HypertensionR01HL128189 · NHLBI · UNIVERSITY OF VIRGINIA · PI KELLER, SUSANNA R · 2016 to 2024
$5.0M
NHLBI NIH HHS R01 HL128189
6 · The paper itself

Abstract

Background Previous studies demonstrated that angiotensin (Ang) III , not Ang II , is the predominant endogenous agonist for Ang type-2 receptor ( AT

Indexed as

Angiotensin IIIAnimalsArterial PressureDisease Models, AnimalFemaleKidneyMaleNatriuresisPhosphorylationPrehypertensionRats, Inbred SHRRats, Inbred WKYReceptor, Angiotensin, Type 2Renin-Angiotensin SystemSignal TransductionSodium-Hydrogen Exchanger 3Angiotensin IIIReceptor, Angiotensin, Type 2Slc9a3 protein, ratSodium-Hydrogen Exchanger 3Sodium-Potassium-Exchanging ATPaseangiotensinangiotensin receptorhypertensionnatriuretic hormonerenal physiology

Identifiers

PMID31039659
PMCPMC6512109
OpenAlexW2943528153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.