ArticleExperimental neurology2019
Dysregulation of mechanosensory circuits coordinating the actions of antagonist motor pools following peripheral nerve injury and muscle reinnervation.
Article in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 17 citations in OpenAlex.
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- Computing muscle mechanical state variables from combined proprioceptive sensory feedback.Experimental physiology · 2025Article
- An assessment of co-contraction in reinnervated muscle.Regenerative medicine · 2024Article
- Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Clinical Significance of Genetic Variation in Ovarian Cancer.International journal of molecular sciences · 2023Article
- Structural Preservation Does Not Ensure Function at Sensory Ia-Motoneuron Synapses following Peripheral Nerve Injury and Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Mechanosensory encoding dysfunction emerges from cancer-chemotherapy interaction.Frontiers in molecular biosciences · 2022Article
- Normal Development and Pathology of Motoneurons: Anatomy, Electrophysiological Properties, Firing Patterns and Circuit Connectivity.Advances in neurobiology · 2022Article
- Neural circuit mechanisms of sensorimotor disability in cancer treatment.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Effects of route of administration on neural exposure to platinum-based chemotherapy treatment: a pharmacokinetic study in rat.Neurotoxicology · 2021Article
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- Chronic defects in intraspinal mechanisms of spike encoding by spinal motoneurons following chemotherapy.Experimental neurology · 2020Article
- Synaptic Plasticity on Motoneurons After Axotomy: A Necessary Change in Paradigm.Frontiers in molecular neuroscience · 2020Review
- Adaptation of muscle activation after patellar loading demonstrates neural control of joint variables.Scientific reports · 2019Article
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3 authors at 2 institutions in 1 country.
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Abstract
Movement disorders observed following peripheral nerve injury and muscle reinnervation suggest discoordination in the activation of antagonist muscles. Although underlying mechanisms remain undecided, dysfunction in spinal reflex circuits is a reasonable candidate. Based on the well known role of reflex inhibition between agonist and antagonist muscles in normal animals, we hypothesized its reduction following muscle reinnervation, similar to that associated with other disorders exhibiting antagonist discoordination, e.g. spinal cord injury and dystonia. Experiments performed on acutely-decerebrated rats examined interactions of mechanosensory reflexes between ipsilateral muscles acting as mechanical antagonists at the ankle joint: ankle extensor, gastrocnemii (G) muscles (agonists) and ankle flexor, tibialis anterior (TA) muscle (antagonist). The force of agonist stretch reflex contraction was measured for its suppression or facilitation by concurrent conditioning stretch of the antagonist muscle. Data were compared between two groups of adult rats, an antagonist reinnervation group with TA muscle reinnervated and a control group with TA normally innervated. Results revealed a three-fold increase in reflex suppression in the antagonist reinnervation group, contrary to our predicted decrease. Reflex facilitation also increased, not only in strength, seven-fold, but also in its frequency of stochastic occurrence across stimulus trials. These observations suggest dysregulation in specific spinal reflex circuits as novel candidate origins of modified antagonist muscle coordination following peripheral nerve injury and muscle reinnervation.
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