Evidence map›Paper›PMID 31039310›Full record

ArticleThe journal of physical chemistry letters2019

Terahertz Spectroscopy of Tetrameric Peptides.

Jens Neu, Elizabeth A Stone, Jacob A Spies, Golo Storch, Ayaka S Hatano, Brandon Q Mercado, Scott J Miller, Charles A Schmuttenmaer

Abstract read
In one paragraph

Article in The journal of physical chemistry letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jens NeuDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.ORCID http://orcid.org/0000-0002-1054-0444
Elizabeth A StoneDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
Jacob A SpiesDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
Golo StorchDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.ORCID http://orcid.org/0000-0002-6747-3035
Ayaka S HatanoDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
Brandon Q MercadoDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
Scott J MillerDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.ORCID http://orcid.org/0000-0001-7817-1318
Charles A SchmuttenmaerDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.ORCID http://orcid.org/0000-0001-9992-8578

Funding

PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Site-Selective Catalysis for Organic SynthesisR37GM068649 · NIGMS · YALE UNIVERSITY · PI MILLER, SCOTT J · 2011 to 2018
$2.7M
Predoctoral Program in BiophysicsT32GM149438 · NIGMS · YALE UNIVERSITY · PI Yong Xiong, Elsa Chui Ying Yan · 2023 to 2026
$2.6M
Selective Peptide-Based Oxidation Catalysts for Bioactive Molecule SynthesisR01GM096403 · NIGMS · YALE UNIVERSITY · PI MILLER, SCOTT J · 2011 to 2018
$2.4M
Site-Selective Catalysts for Organic SynthesisR01GM068649 · NIGMS · YALE UNIVERSITY · PI MILLER, SCOTT J · 2003 to 2010
$2.3M
NIGMS NIH HHS R01 GM068649NIGMS NIH HHS R01 GM096403NIGMS NIH HHS R37 GM068649NIGMS NIH HHS T32 GM008283NIGMS NIH HHS T32 GM149438
6 · The paper itself

Abstract

Determining the sequence and structure of peptides is crucial for understanding their structure-property relationships. Among many techniques, structures are typically elucidated using nuclear magnetic resonance spectroscopy and single crystal X-ray diffraction measurements. In this study, we present terahertz time-domain spectroscopy (THz-TDS) as a complementary, nondestructive technique that is sensitive to both the primary and secondary structures of tetrapeptides. Using only a few milligrams of peptide, THz-TDS spectra have been measured, some of which have been supported by density functional theory (DFT) calculations, to distinguish six tetrameric peptides with similar primary and secondary structures.

Indexed as

Terahertz SpectroscopyDensity Functional TheoryPeptidesProtein ConformationPeptides

Identifiers

PMID31039310
PMCPMC6936601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.