ArticlePloS one2019
A preliminary report of longitudinal white matter alterations in patients with end-stage renal disease: A three-year diffusion tensor imaging study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Relationship of Estimated Glomerular Filtration Rate (eGFR) and Neuron-Specific Enolase (NSE) with Cognitive Dysfunction in Type 2 Diabetes Mellitus: A Cross-Sectional Analysis.International journal of general medicine · 2026Article
- Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Reduced functional connectivity induced by longitudinal alterations of structure and perfusion may be associated with cognitive impairment in patients on maintenance hemodialysis.Brain imaging and behavior · 2024Article
- Longitudinal changes in diffusion tensor imaging in hemodialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2024Article
- Assessing brain microstructural changes in chronic kidney disease: a diffusion imaging study using multiple models.Frontiers in neurology · 2024Article
- Abnormal white matter along fibers by automated fiber quantification in patients undergoing hemodialysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- The effects of the dialysis on the white matter tracts in patients with end-stage renal disease using differential tractography study.Scientific reports · 2023Article
- Characterization of diffusion MRI using the mean apparent propagator model in hemodialysis patients: A pilot study.Magnetic resonance imaging · 2023Article
- Structural brain abnormalities in children and young adults with severe chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Positive coping style reduction in elderly end-stage renal disease patients: mediating role of white matter mean diffusivity.Neuroradiology · 2022Article
- Global and Regional White Matter Fractional Anisotropy in Children with Chronic Kidney Disease.The Journal of pediatrics · 2022Article
- Long-term hemodialysis may affect enlarged perivascular spaces in maintenance hemodialysis patients: evidence from a pilot MRI study.Quantitative imaging in medicine and surgery · 2022Article
- Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study.Frontiers in human neuroscience · 2021Article
- Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study.Frontiers in neuroscience · 2021Article
- Diffusion Tensor Imaging Features of Watershed Segmentation Algorithm for Analysis of the Relationship between Depression and Brain Nerve Function of Patients with End-Stage Renal Disease.Journal of healthcare engineering · 2021Article
- Structural and Functional Alterations in Hemodialysis Patients: A Voxel-Based Morphometry and Functional Connectivity Study.Frontiers in human neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEnd-stage renal disease (ESRD) patients exhibit silent white-matter alterations after long-term hemodialysis, which may be due to ESRD itself or the hemodialysis. The purpose of this study was to investigate the longitudinal white-matter alterations in the ESRD patients under 3-year long-term hemodialysis using voxel-wise analysis of diffusion tensor imaging (DTI). MATERIALS AND
methods15 ESRD patients and 15 age-matched healthy controls participated in this study. Due to the development of abnormal brain lesions in some cases, 13 ESRD patients and 13 age-matched healthy controls were enrolled and underwent cognitive function assessment and DTI acquisition at two-time points separated by 3 years. Voxel-based analysis was performed to globally detect white-matter alterations between the two groups as well as between the two scans within the two groups.
resultsIn the ESRD patients, diffusivity indices were significantly increased and the fractional anisotropy was significantly decreased in both scans, as compared with healthy controls. Longitudinal comparisons showed significant white-matter alterations in healthy controls in three years, but little or no significant alterations were noted in the ESRD patients after additional 3-year hemodialysis.
conclusionPoorer white matter integrity and cognitive function are noted in ESRD patients and the toxic effect of ESRD may be the major factor of white matter alterations.
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