Evidence map›Paper›PMID 31039131›Full record

ArticleAging2019

Identification of inflammatory and vascular markers associated with mild cognitive impairment.

Xue-Ning Shen, Yanxia Lu, Crystal Tze Ying Tan, Ling-Yun Liu, Jin-Tai Yu, Lei Feng, Anis Larbi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Preventive Effect of ProbioticAntioxidants (Basel, Switzerland) · 2025
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  16. Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders.International journal of molecular sciences · 2022
    Review
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  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xue-Ning ShenDepartment of Neurology, Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yanxia LuSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Crystal Tze Ying TanSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
Ling-Yun LiuDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jin-Tai YuDepartment of Neurology, Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Lei FengDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Anis LarbiSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biochemical processes have been associated with the pathogenesis of mild cognitive impairment (MCI) and dementia, including chronic inflammation, dysregulation of membrane lipids and disruption of neurotransmitter pathways. However, research investigating biomarkers of these processes in MCI remained sparse and inconsistent. To collect fresh evidence, we evaluated the performance of several potential markers in a cohort of 57 MCI patients and 57 cognitively healthy controls. MCI patients showed obviously increased levels of plasma TNF-α (p = 0.045) and C-peptide (p = 0.004) as well as decreased levels of VEGF-A (p = 0.042) and PAI-1 (p = 0.019), compared with controls. In addition, our study detected significant correlations of plasma sTNFR-1 (MCI + Control: B = -6.529, p = 0.020; MCI: B = -9.865, p = 0.011) and sIL-2Rα (MCI + Control: B = -7.010, p = 0.007; MCI: B = -11.834, p = 0.003) levels with MoCA scores in the whole cohort and the MCI group. These findings corroborate the inflammatory and vascular hypothesis for dementia. Future studies are warranted to determine their potential as early biomarkers for cognitive deficits and explore the related mechanisms.

Indexed as

AgedBiomarkersCognitionCognitive DysfunctionFemaleHumansInflammationMaleMiddle AgedNeuropsychological TestsPlasminogen Activator Inhibitor 1Receptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor-alphaVascular Endothelial Growth Factor ABiomarkersPlasminogen Activator Inhibitor 1Receptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor-alphaVascular Endothelial Growth Factor AC-peptidemild cognitive impairmentPAI-1sIL-2RαsTNFR-1TNF-αVEGF-A

Identifiers

PMID31039131
PMCPMC6520012

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.