Evidence map›Paper›PMID 31039056›Full record

ArticleEnvironmental health perspectives2019

Associations between Maternal Tobacco Smoke Exposure and the Cord Blood

Caitlin G Howe, Meng Zhou, Xuting Wang, Gary S Pittman, Isabel J Thompson, Michelle R Campbell, Theresa M Bastain, Brendan H Grubbs, Muhammad T Salam, Cathrine Hoyo and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Epigenetic biomarkers for smoking cessation.Addiction neuroscience · 2023
    Article
  7. Article
  8. Article
  9. Gene-Environment Interactions and Stochastic Variations in the Gero-Exposome.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Caitlin G HoweDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Meng ZhouMolecular and Computational Biology, University of Southern California, Los Angeles, California, USA.
Xuting WangImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Dept. of Health and Human Services, Research Triangle Park, North Carolina, USA.
Gary S PittmanImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Dept. of Health and Human Services, Research Triangle Park, North Carolina, USA.
Isabel J ThompsonImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Dept. of Health and Human Services, Research Triangle Park, North Carolina, USA.
Michelle R CampbellImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Dept. of Health and Human Services, Research Triangle Park, North Carolina, USA.
Theresa M BastainDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Brendan H GrubbsDepartment of Obstetrics and Gynecology, Keck School of Medicine, Los Angeles, California, USA.
Muhammad T SalamDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Cathrine HoyoDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Douglas A BellImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Dept. of Health and Human Services, Research Triangle Park, North Carolina, USA.
Andrew D SmithMolecular and Computational Biology, University of Southern California, Los Angeles, California, USA.
Carrie V BretonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
University of Southern California · USNational Institutes of Health · USKeck Graduate Institute · USNorth Carolina State University · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Discovery And Functional Genomics Of Environmental Response GenesZIAES100475 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BELL, DOUGLAS · 2009 to 2025
$24.4M
Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Andrew R. Binder · 2015 to 2026
$18.3M
Genetic Susceptibility To Carcinogens and ToxicantsZIAES046008 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BELL, DOUGLAS · 2009 to 2021
$7.8M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HABRE, RIMA · 2015 to 2019
$3.7M
Discovery And Genetics Of Environmental Response GenesZ01ES100475 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BELL, DOUGLAS · 2002 to 2008
$2.9M
Prenatal Tobacco Smoke, Genetic and Epigenetic Changes, and Respiratory HealthR01ES022216 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2013 to 2016
$2.0M
Intramural NIH HHS Z01 ES100475NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES025128NIEHS NIH HHS P50 ES026086NIEHS NIH HHS R01 ES022216NIEHS NIH HHS T32 ES013678
6 · The paper itself

Abstract

backgroundMaternal tobacco smoke exposure has been associated with altered DNA methylation. However, previous studies largely used methylation arrays, which cover a small fraction of CpGs, and focused on whole cord blood.

objectivesThe current study examined the impact of in utero exposure to maternal tobacco smoke on the cord blood

methodsThe methylomes of 20 Hispanic white newborns (

resultsWe found that 10,381 CpGs were differentially methylated by tobacco smoke exposure [neighbor-adjusted p-values that are additionally corrected for multiple testing based on the Benjamini-Hochberg method for controlling the false discovery rate (FDR)

conclusionsMaternal tobacco smoke exposure in pregnancy is associated with cord blood

Indexed as

Maternal ExposureAdultCD4-Positive T-LymphocytesDNA MethylationEpigenomeFemaleFetal BloodHumansMaleTobacco Smoke PollutionYoung AdultTobacco Smoke Pollution

Identifiers

PMID31039056
PMCPMC6785223
OpenAlexW2942668417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.