Evidence map›Paper›PMID 31038823›Full record

Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2019

Perceived triggers of asthma impair quality of life in children with asthma.

Hannah M Kansen, Thuy-My Le, Yolanda Meijer, Cuno S P M Uiterwaal, André C Knulst, Cornelis K van der Ent, Francine C van Erp

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Perceived triggers of asthma impair quality of life in children with asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Trial
  3. Observational
  4. Review
  5. Psychological and Sociocultural Determinants in Childhood Asthma Disease: Impact on Quality of Life.International journal of environmental research and public health · 2022
    Review
  6. Evaluation of a Program to Reduce Home Environment Risks for Children with Asthma Residing in Urban Areas.International journal of environmental research and public health · 2021
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hannah M KansenDepartment of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0003-1446-7704
Thuy-My LeDepartment of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.
Yolanda MeijerDepartment of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Cuno S P M UiterwaalJulius Center for Health Science and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
André C KnulstDepartment of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.
Cornelis K van der EntDepartment of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Francine C van ErpDepartment of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-2209-5608

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData on the impact of the number and nature of perceived asthma triggers on health-related quality of life (HRQL) in children are scarce.

objectiveTo investigate the impact of perceived asthma triggers on both asthma-specific and generic HRQL in children.

methodsA cross-sectional study was conducted among children (7-18 years) with asthma in secondary and tertiary care. Children were screened with electronic questionnaires regarding respiratory and allergic symptoms. Asthma-specific HRQL was assessed using the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) (score range 1-7) and generic HRQL using the RAND questionnaire (score range 7-32). The Kruskal-Wallis test and one-way ANOVA were used to test the difference of, respectively, the PAQLQ and RAND scores across the number of perceived asthma triggers (0, 1-2, 3-4, or ≥ 5). Univariable and multivariable linear regression analyses were performed to evaluate the association between individual triggers and HRQL.

resultsA total of 527 children with a mean (SD) age of 12.1 (2.9) years were included. Children with a higher number of perceived triggers had significantly lower PAQLQ and RAND scores (ie poorer HRQL). The difference in PAQLQ scores was clinically relevant between children with 0 versus 3-4 or ≥ 5 triggers and 1-2 versus ≥ 5 triggers (mean difference 0.66, 1.02 and 0.63, respectively). Especially, non-allergic triggers (physical exercise, the weather, (cigarette) smoke and emotions) were significantly associated with reduced PAQLQ scores. Emotions and food/drinks were associated with reduced RAND scores. CONCLUSION AND CLINICAL RELEVANCE: A higher number of perceived triggers of asthma were associated with reduced HRQL in children with asthma. Especially, non-allergic triggers were associated with reduced HRQL.

Indexed as

AsthmaQuality of LifeSurveys and QuestionnairesAdolescentChildFemaleHumansMaleasthmapaediatricsquality of life

Identifiers

PMID31038823
PMCPMC6851977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.