Evidence map›Paper›PMID 31038584›Full record

ArticleActa cirurgica brasileira2019

Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream.

Carlos Augusto Real Martinez, Fábio Guilherme Campos, Danilo Toshio Kanno, Eli Cristiano Meneses, Gabrielle Maira Matijascic, Eduardo Felipe Kim Goto, José Aires Pereira

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Carlos Augusto Real MartinezPhD, Associate Professor, Postgraduate Program in Health Sciences, Universidade São Francisco (USF), Bragança Paulista-SP, and Department of Surgery, Universidade Estadual de Campinas (UNICAMP), Campinas-SP, Brazil. Conception and design of the study, statistics analysis, interpretation of data, manuscript preparation and writing, critical revision.ORCID http://orcid.org/0000-0001-8088-427X
Fábio Guilherme CamposPhD, Associate Professor, Department of Gastroenterology, Faculty of Medicine, Universidade de São Paulo (USP), Brazil. Interpretation of data, critical revision.ORCID http://orcid.org/0000-0002-6233-6904
Danilo Toshio KannoFellow Master degree, Assistant Professor, Division of Surgery, Faculty of Medicine, USF, Bragança Paulista-SP, Brazil. Technical procedures, acquisition of data.ORCID http://orcid.org/0000-0001-7120-4017
Eli Cristiano MenesesFellow Master degree, Assistant Professor, Faculty of Pharmacology, USF, Bragança Paulista-SP, Brazil. Technical procedures, acquisition of data.ORCID http://orcid.org/0000-0003-4395-0623
Gabrielle Maira MatijascicGraduate student, Faculty of Medicine, USF, Bragança Paulista-SP, Brazil. Technical procedures, acquisition of data.ORCID http://orcid.org/0000-0002-9270-1837
Eduardo Felipe Kim GotoGraduate student, Faculty of Medicine, USF, Bragança Paulista-SP, Brazil. Technical procedures, acquisition of data.ORCID http://orcid.org/0000-0002-1218-1035
José Aires PereiraPhD, Assistant Professor, Division of Pathology, Faculty of Medicine, USF, Bragança Paulista-SP, Brazil. Histopathological examinations, acquisition and interpretation of data.ORCID http://orcid.org/0000-0003-3937-7182
Santa Casa da Misericórdia de Bragança Paulista · BRUniversidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the inflammatory reaction and measure the content of mucins, in the colonic mucosa without fecal stream submit to intervention with mesalazine.

methodsTwenty-four rats were submitted to a left colostomy and a distal mucous fistula and divided into two groups according to euthanasia to be performed two or four weeks. Each group was divided into two subgroups according daily application of enemas containing saline or mesalazine at 1.0 g/kg/day. Colitis was diagnosed by histological analysis and the inflammatory reaction by validated score. Acidic mucins and neutral mucins were determined with the alcian-blue and periodic acid of Schiff techniques, respectively. Sulfomucin and sialomucin were identified by high iron diamine-alcian blue technique. The tissue contents of mucins were quantified by computer-assisted image analysis. Mann-Whitney test was used to analyze the results establishing the level of significance of 5%.

resultsEnemas with mesalazine in colonic segments without fecal stream decreased the inflammation score and increased the tissue content of all subtypes of mucins. The increase of tissue content of neutral, acid and sulfomucin was related to the time of intervention.

conclusionMesalazine enemas reduce the inflammatory process and preserve the content of mucins in colonic mucosa devoid of fecal stream.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalColitisColonColostomyEnemaFecesGastrointestinal TransitHistocytochemistryImage Processing, Computer-AssistedIntestinal MucosaMaleMesalamineMucinsOxidative StressRats, WistarAnti-Inflammatory Agents, Non-SteroidalMesalamineMucins

Identifiers

PMID31038584
PMCPMC6583918
OpenAlexW2943672482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.