ArticleArquivos brasileiros de cardiologia2019
Resistance Exercise Modulates Oxidative Stress Parameters and TNF-α Content in the Heart of Mice with Diet-Induced Obesity.
Article in Arquivos brasileiros de cardiologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Resistance Exercise Training Mitigates Cardiac Remodeling Induced by a High-Fat Diet in Rodents: A Systematic Review.Arquivos brasileiros de cardiologia · 2024Pooled it
- Efficacy and Safety of Resistance Training for Coronary Heart Disease Rehabilitation: A Systematic Review of Randomized Controlled Trials.Frontiers in cardiovascular medicine · 2021Pooled it
- Effects of resistance exercise on treatment outcome and laboratory parameters of Takayasu arteritis with magnetic resonance imaging diagnosis: A randomized parallel controlled clinical trial.Clinical cardiology · 2020Trial
- Mechanistic Role of Sestrin2 in Exercise-Mediated Cardioprotection Against Obesity-Related Cardiomyopathy.International journal of molecular sciences · 2026Article
- Resistance Exercise: A Potential Intervention for Managing Cardiovascular Health in Individuals with a History of Cancer.Sports medicine - open · 2026Article
- Animal Models of Exercise and Cardiometabolic Disease.Circulation research · 2025Review
- High-Fat Diet and Heart: What is the Real Impact of Resistance Exercise Training?Arquivos brasileiros de cardiologia · 2024Article
- Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice.Nutrients · 2022Article
- Potential Effects of Resistant Exercise on Cognitive and Muscle Functions Mediated by Myokines in Sarcopenic Obese Mice.Biomedicines · 2022Article
- Article
- Resistance Exercise Training Improves Metabolic and Inflammatory Control in Adipose and Muscle Tissues in Mice Fed a High-Fat Diet.Nutrients · 2022Article
- Unveiling the role of exercise training in targeting the inflammatory paradigm of heart failure with preserved ejection fraction: a narrative review.Heart failure reviews · 2022Review
- Supplementation of Vitamin D.Arquivos brasileiros de cardiologia · 2021Article
- Post-resistance exercise photobiomodulation therapy has a more effective antioxidant effect than pre-application on muscle oxidative stress.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Article
- The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration.Frontiers in cell and developmental biology · 2021Review
- Strength Training Reduces Cardiac and Renal Oxidative Stress in Rats with Renovascular Hypertension.Arquivos brasileiros de cardiologia · 2021Article
- Overview of Recent Advances in Experimental Cardiovascular Research.Arquivos brasileiros de cardiologia · 2020Article
- The Top 10 Original Articles Published in the Arquivos Brasileiros de Cardiologia and in the Revista Portuguesa de Cardiologia in 2019.Arquivos brasileiros de cardiologia · 2020Article
- Cardioprotective Effects of Resistance Training on Obesity.Arquivos brasileiros de cardiologia · 2019Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity can be characterized by low-grade chronic inflammation and is associated with an excesso production of reactive oxygen species, factors that contribute to coronary heart disease and other cardiomyopathies.
objectiveTo verify the effects of resistance exercise training on oxidative stress and inflammatory parameters on mice with obesity induced by a high-fat diet (HFD).
methods24 Swiss mice were divided into 4 groups: standard diet (SD), SD + resistance exercise (SD + RE), diet-induced obesity (DIO), DIO + RE. The animals were fed SD or HFD for 26 weeks and performed resistance exercises in the last 8 weeks of the study. The insulin tolerance test (ITT) and body weight monitoring were performed to assess the clinical parameters. Oxidative stress and inflammation parameters were evaluated in the cardiac tissue. Data were expressed by mean and standard deviation (p < 0.05).
resultsThe DIO group had a significant increase in reactive oxygen species levels and lipid peroxidation with reduction after exercise. Superoxide dismutase and the glutathione system showed no significant changes in DIO animals, with an increase in SD + RE. Only catalase activity decreased with both diet and exercise influence. There was an increase in tumor necrosis factor-alpha (TNF-α) in the DIO group, characterizing a possible inflammatory condition, with a decrease when exposed to resistance training (DIO+RE).
conclusionThe DIO resulted in a redox imbalance in cardiac tissue, but the RE was able to modulate these parameters, as well as to control the increase in TNF-α levels.
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