Evidence map›Paper›PMID 31038495›Full record

ArticleChemical communications (Cambridge, England)2019

The lipid phase preference of the adenosine A

M Gertrude Gutierrez, Jacob Deyell, Kate L White, Lucia C Dalle Ore, Vadim Cherezov, Raymond C Stevens, Noah Malmstadt

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. The Role of Lipids in Allosteric Modulation of Dopamine DMolecules (Basel, Switzerland) · 2022
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

M Gertrude GutierrezMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA. malmstadt@usc.edu.
Jacob Deyell
Kate L White
Lucia C Dalle Ore
Vadim Cherezov
Raymond C Stevens
Noah Malmstadt
University of Southern California · US

Funding

Effects of lipidomic diversity on GPCRR01GM120351 · NIGMS · UNIVERSITY OF DELAWARE · PI LYMAN, EDWARD RAY · 2017 to 2021
$1.6M
NIGMS NIH HHS R01 GM120351
6 · The paper itself

Abstract

Giant unilamellar protein vesicles (GUPs) were formed with the adenosine A2A receptor (A2AR) incorporated in the lipid bilayer and protein partitioning into the liquid ordered and liquid disordered phases was observed. When no ligand is bound, A2AR partitions preferentially into the liquid disordered phase of GUPs, while ligand-bound A2AR partitions into the liquid ordered phase.

Indexed as

AnimalsBinding SitesHEK293 CellsHumansLigandsLipid BilayersLipidsPhase TransitionProtein BindingReceptors, Adenosine A2Sf9 CellsLigandsLipid BilayersLipidsReceptors, Adenosine A2

Identifiers

PMID31038495
PMCPMC6561478
OpenAlexW2943832245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.