ArticleMicrobial genomics2019
Caribbean multi-centre study of Klebsiella pneumoniae: whole-genome sequencing, antimicrobial resistance and virulence factors.
Article in Microbial genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Carbapenemases: epidemiology, detection and management in a changing global landscape.JAC-antimicrobial resistance · 2026Review
- Bone and Joint Infections in Tropical Settings: High Prevalence of Gram-Negative Bacilli and Implications for Empirical Therapy.Open forum infectious diseases · 2026Article
- Targeted phage aerosol for environmental control of CR-Kpn in the ICU: a prospective intervention study.Frontiers in public health · 2026Article
- Emerging carbapenem-resistantMicrobiology spectrum · 2025Article
- Review
- Virulence Factors inIndian journal of microbiology · 2024Review
- Article
- The burden of antimicrobial resistance in the Americas in 2019: a cross-country systematic analysis.Lancet regional health. Americas · 2023Article
- Article
- Molecular Epidemiology of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Limited Transmission of Klebsiella pneumoniae among Humans, Animals, and the Environment in a Caribbean Island, Guadeloupe (French West Indies).Microbiology spectrum · 2022Article
- Emergence of a Novel Lineage and Wide Spread of aAntibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance and Virulence Characteristics ofPathogens (Basel, Switzerland) · 2022Article
- Genomic and antigenic diversity of colonizingMicrobial genomics · 2022Article
- Reporting on antibiotic use patterns using the WHO Access, Watch, Reserve classification in the Caribbean.Revista panamericana de salud publica = Pan American journal of public health · 2022Article
- Prevalence and distribution of ampc beta-lactamase producingFrontiers in cellular and infection microbiology · 2022Article
- One Health Genomic Study of Human and AnimalAntibiotics (Basel, Switzerland) · 2021Article
- Eight years of antibiotic consumption at a primary care outpatient facility in Trinidad and Tobago 2011-18: a synopsis of consumption trends.JAC-antimicrobial resistance · 2021Article
- Impact of a restrictive antibiotic policy on the acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an endemic region: a before-and-after, propensity-matched cohort study in a Caribbean intensive care unit.Critical care (London, England) · 2021Observational
- A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex.Nature communications · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The surveillance of antimicrobial-resistant isolates has proven to be one of the most valuable tools to understand the global rise of multidrug-resistant bacterial pathogens. We report the first insights into the current situation in the Caribbean, where a pilot project to monitor antimicrobial resistance (AMR) through phenotypic resistance measurements combined with whole-genome sequencing was set up in collaboration with the Caribbean Public Health Agency (CARPHA). Our first study focused on Klebsiella pneumoniae, a highly relevant organism amongst the Gram-negative opportunistic pathogens worldwide causing hospital- and community-acquired infections. Our results show that not only carbapenem resistance, but also hypervirulent strains, are circulating in patients in the Caribbean. Our current data does not allow us to infer their prevalence in the population. We argue for the urgent need to further support AMR surveillance and stewardship in this almost uncharted territory, which can make a significant impact on the reduction of antimicrobial usage. This article contains data hosted by Microreact (https://microreact.org).
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