Evidence map›Paper›PMID 31038368›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2019

Institutional protocols for the oral administration (gavage) of chemicals and microscopic microbial communities to mice: Analytical consensus.

Alexander Rodriguez-Palacios, Mikhail V Khoretonenko, Sanja Ilic

Abstract readReviewConsensus Statement
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Current Sampling Methods for Gut Microbiota: A Call for More Precise Devices.Frontiers in cellular and infection microbiology · 2020
    Review
  6. Microbiome: Our opponents or allies in healthcare and medicine.Experimental biology and medicine (Maywood, N.J.) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander Rodriguez-Palacios1 Division of Gastroenterology and Liver Diseases, Department of Medicine, and Digestive Diseases Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID 0000-0003-0713-5605
Mikhail V Khoretonenko3 Department of Biology, Lakeland Community College, Kirtland, OH 44094, USA.
Sanja Ilic4 Department of Human Sciences and Nutrition, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3450-2693

Funding

Ubiquitination Pathways Mediating Chronic Intestinal InflammationP01DK091222 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RODRIGUEZ-PALACIOS, ALEXANDER · 2011 to 2020
$16.5M
Identification of Pathogenic Bacteria in Crohn's DiseaseR21DK118373 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RODRIGUEZ-PALACIOS, ALEXANDER · 2018 to 2020
$601k
NIDDK NIH HHS P01 DK091222NIDDK NIH HHS R21 DK118373
6 · The paper itself

Abstract

impact statementInstitutional protocols designed for the oral administration of live microbial communities, either complex or microscopic (microcosmic), to mice do not exist. However, this approach is increasingly employed by investigators focusing on the gut microbiome in experimental research. Herein, we propose two analytically Kappa-based consensus protocols to promote reproducibility and standardization in research practices and describe biologically relevant factors in achieving optimal microbial engraftment of communities in germ-free mice.

Indexed as

MicrobiotaModels, AnimalAdministration, OralAnimalsGerm-Free LifeMiceMicrobiological Techniquesfecal matter transplantGavagegnotobioticinflammatory bowel diseasemicrobiomemouse models

Identifiers

PMID31038368
PMCPMC6547009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.