ArticleActa paediatrica (Oslo, Norway : 1992)2019
Presence of Giardia lamblia in stools of six- to 18-month old asymptomatic Malawians is associated with children's growth failure.
Article in Acta paediatrica (Oslo, Norway : 1992), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Effects of lipid-based nutrient supplements on gut markers in stunted children: Secondary analysis of a randomised trial.Journal of pediatric gastroenterology and nutrition · 2025Trial
- Early-life immunological and microbial differences between East African and North European children.Communications medicine · 2026Article
- Current Understanding ofCurrent tropical medicine reports · 2024Article
- Giardia duodenalis in Ugandan Children Aged 9-36 Months in Kampala, Uganda: Prevalence and Associated Factors.The American journal of tropical medicine and hygiene · 2023Article
- Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children.Maternal & child nutrition · 2023Article
- Giardia lamblia-infected preschoolers present growth delays independent of the assemblage A, B or E.Memorias do Instituto Oswaldo Cruz · 2023Article
- A scoping review of risk factors and transmission routes associated with human giardiasis outbreaks in high-income settings.Current research in parasitology & vector-borne diseases · 2022Article
- Anthropometric Indices of Giardia-Infected Under-Five Children Presenting with Moderate-to-Severe Diarrhea and Their Healthy Community Controls: Data from the Global Enteric Multicenter Study.Children (Basel, Switzerland) · 2021Article
- Molecular Detection and Characterization ofPathogens (Basel, Switzerland) · 2021Article
- Rotavirus Infection, Illness, and Vaccine Performance in Malnourished Children: A Review of the Literature.The Pediatric infectious disease journal · 2021Review
- Impact of sampling depth on pathogen detection in pit latrines.PLoS neglected tropical diseases · 2021Article
- Benefits and Risks of Smallholder Livestock Production on Child Nutrition in Low- and Middle-Income Countries.Frontiers in nutrition · 2021Review
- Natural Infection withmSphere · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
aimDespite high pathogen burden and malnutrition in low-income settings, knowledge on relationship between asymptomatic viral or parasitic infections, nutrition and growth is insufficient. We studied these relationships in a cohort of six-month-old Malawian infants.
methodsAs part of a nutrient supplementation trial for 12 months, we documented disease symptoms of 840 participant daily and anthropometric measurements every three months. Stool specimens were collected every six months and analysed for Giardia lamblia, Cryptosporidium species and enterovirus, rotavirus, norovirus, parechovirus and rhinovirus using polymerase chain reaction (PCR). The prevalence of the microbes was compared to the children's linear growth and the dietary.
resultsThe prevalence of the microbes was similar in every intervention group. All age groups combined, children negative for G. lamblia had a mean standard deviation (SD) of -0.01 (0.49) change in length-for-age Z-score (LAZ), compared to -0.12 (0.045) among G. lamblia positive children (difference -0.10, 95% CI -0.21 to -0.00, p = 0.047). The LAZ change difference was also statistically significant (p = 0.042) at age of 18-21 months but not at the other time points.
conclusionAsymptomatic G. lamblia infection was mainly associated with growth reduction in certain three-month periods. The result refers to the chronic nature of G. lamblia infection.
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