Evidence map›Paper›PMID 31038124›Full record

ArticleeLife2019

Host-pathogen coevolution increases genetic variation in susceptibility to infection.

Elizabeth Ml Duxbury, Jonathan P Day, Davide Maria Vespasiani, Yannik Thüringer, Ignacio Tolosana, Sophia Cl Smith, Lucia Tagliaferri, Altug Kamacioglu, Imogen Lindsley, Luca Love and 3 more

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Parasite defense covaries with reproductive timing, not with resistance.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Natural selection has driven the recurrent loss of an immunity gene that protectsProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. A novel transposable element-mediated mechanism causes antiviral resistance inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Genetic diversity and disease: The past, present, and future of an old idea.Evolution; international journal of organic evolution · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elizabeth Ml Duxbury *Department of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-5733-3645
Jonathan P Day *Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
Davide Maria VespasianiDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Yannik ThüringerDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Ignacio TolosanaDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-3766-8296
Sophia Cl SmithDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Lucia TagliaferriDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Altug KamaciogluDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Imogen LindsleyDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Luca LoveDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Robert L UncklessDepartment of Molecular Biosciences, University of Kansas, Lawrence, United States.ORCID 0000-0001-8586-7137
Francis M JigginsDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-7470-8157
Ben LongdonDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-6936-1697

Funding

The causes of balancing selection on immunity genes: from populations to molecular interactions.R01AI139154 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI UNCKLESS, ROBERT L · 2018 to 2022
$1.9M
Antimicrobial peptides as models for the evolution of gene duplicationR00GM114714 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI UNCKLESS, ROBERT L · 2016 to 2018
$732k
NIAID NIH HHS R01 AI139154NIGMS NIH HHS R00 GM114714Wellcome Trust
6 · The paper itself

Abstract

It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of

Indexed as

Disease SusceptibilityGenetic VariationAllelesAnimalsChromosome MappingDisease ResistanceDrosophila melanogasterFemaleGenes, InsectHost-Pathogen InteractionsInfectionsMalePolymorphism, GeneticRhabdoviridaeRhabdoviridae InfectionsSelection, GeneticcoevolutionD. melanogasterDrosophilaevolutionary biologysigma virusvirusviruses

Identifiers

PMID31038124
PMCPMC6491035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.