Evidence map›Paper›PMID 31037918›Full record

ArticleInternational journal of fertility & sterility2019

Correlation of Copper and Zinc in Spontaneous Abortion.

Riddhi Thaker, Hina Oza, Idrish Shaikh, Sunil Kumar

Open access · greenAbstract read
In one paragraph

Article in International journal of fertility & sterility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Australasian recurrent pregnancy loss clinical management guideline 2024, part II.The Australian & New Zealand journal of obstetrics & gynaecology · 2024
    Guideline
  2. Pooled it
  3. Copper homeostasis and pregnancy complications: a comprehensive review.Journal of assisted reproduction and genetics · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Maternal Serum Zinc, Copper, Magnesium, and Iron in Spontaneous Abortions.Indian journal of clinical biochemistry : IJCB · 2023
    Article
  9. Article
  10. Article
  11. Definition and Multiple Factors of Recurrent Spontaneous Abortion.Advances in experimental medicine and biology · 2021
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Riddhi ThakerDivision of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, India.
Hina OzaDepartment of Obstetrics and Gynecology, Civil Hospital, Ahmedabad, India.
Idrish ShaikhDivision of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, India.
Sunil KumarDivision of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, India. Electronic Address: sunilnioh@gmail.com.
Ahmedabad Civil Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHumans require minute amounts of trace metals to maintain body's normal growth and physiological functions; such elements may also play a vital role in pregnancy and pregnancy outcome. The present study was conducted to assess the role of two trace metals, zinc (Zn) and copper (Cu) in women with history of spontaneous abortion (SAb cases) in comparison to women without such history (controls). MATERIALS AND

methodsIn this retrospective study, a total of 277 subjects were enrolled from the Obstetrics and Gynecology Department, Civil Hospital, Ahmedabad, India. Personal demographic information, medical history, reproductive history especially details of number of SAb, duration of last SAb, number of children, etc. were recorded using predesigned and pre-tested proforma. Serum Zn and Cu levels were measured by an atomic absorption spectrophotometer.

resultsThe data indicated that the serum level of Cu (P<0.01) and Zn was lower in SAb cases as compared to controls. Correlation between the number of SAbs and trace metals levels showed a significant negative correlation between Cu and Cu/Zn and the number of SAbs. Cu/Zn was higher in controls and women having at least one child as compared cases and women without child, respectively. Pregnant women had higher levels of trace elements as compared to non-pregnant women at the time of enrollment.

conclusionThe data revealed that trace metals such as Zn and Cu have a positive role in pregnancy outcome and optimum levels of Zn and Cu might be able to decline the chances of SAb occurrence in addition to other factors. The ratio of Cu/Zn has a positive role in reproductive outcomes.

Indexed as

CopperPregnancy OutcomeSpontaneous AbortionTrace ElementsZinc

Identifiers

PMID31037918
PMCPMC6500075
OpenAlexW2990984115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.