ArticleObesity surgery2019
Dynamic Adaptive Changes of the Ileum Transposed to the Proximal Small Intestine in Rats.
Article in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Bariatric surgery for treatment of morbid obesity in adults.The Korean journal of internal medicine · 2025Review
- East Asian perspectives in metabolic and bariatric surgery.Journal of diabetes investigation · 2022Review
- Reverse Transposition - a New Surgical Model for the Study the Role of Ileum in Glucose Metabolism.Bulletin of experimental biology and medicine · 2022Article
- Article
- Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle.Scientific reports · 2021Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIleal transposition (IT) is an experimental surgery to investigate the role of the distal ileum in Roux-en-Y gastric bypass (RYGB) surgery. To systematically investigate the dynamic adaptation process of the ileum after IT, we performed transcriptome analyses of the transposed ileum compared with the ileum in situ at different postoperative time points.
methodsSprague-Dawley rats fed a chow diet underwent IT or sham surgery. One and 4 weeks after IT or sham surgery, total RNA was extracted from the ileal tissue and subjected to transcriptome analyses using microarray.
resultsPrincipal component analysis showed that the difference between weeks 1 and 4 was the largest, and the differences between the IT and sham groups were larger in week 4 than in week 1. We identified 1792 differentially expressed genes (DEGs) between IT and sham ileal tissues, including 659 and 1133 DEGs in weeks 1 and 4, respectively. Interestingly, only 45 and 24 DEGs were commonly up- or downregulated in weeks 1 and 4, indicating a marked transition during the adaptation process. Functional enrichment and network analyses showed that structural adaptation predominantly occurred in week 1, while metabolic and immune adaptations predominantly occurred in week 4. These analyses further revealed potential components that modulate structural adaptation (e.g., extracellular matrix) in week 1 and metabolic (e.g., glucose transporter) and immune (e.g., Th17 cells) adaptations in week 4.
conclusionsThe transposed distal ileum underwent dynamic adaptation processes that may help explain the metabolic changes after RYGB.
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