ArticleDigestive diseases and sciences2019
Content Validity and Reliability of a Self-Report Measure of Medication Nonadherence in Hepatitis C Treatment.
Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07397260 (Effects of Manually Recorded or Automatically Transmitted Home Blood Pressures With or Without Automated Patient Feedback on Hypertension Care), which is not on this map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Manually Recorded or Automatically Transmitted Home Blood Pressures With or Without Automated Patient Feedback on Hypertension Care
Who cites it
31 citing papers in PubMed.
- Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial.JAMA network open · 2026Trial
- A Pragmatic, Randomized Controlled Trial of Oral Antivirals for the Treatment of Chronic Hepatitis C: The PRIORITIZE Study.Hepatology (Baltimore, Md.) · 2021Trial
- Low-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial.BMC family practice · 2021Trial
- A stepped wedge trial of efficacy and scalability of a virtual clinical pharmacy service (VCPS) in rural and remote NSW health facilities.BMC health services research · 2020Trial
- Self-Reported Adherence to Cancer Therapy: Development and Validation of the Domains of Subjective Extent of Nonadherence-Cancer Measure.JCO oncology practice · 2026Article
- Article
- A Systematic Review of Methods to Measure Adherence to Oral Anticancer Medications in African Women With Breast Cancer at Initiation, Implementation, and Discontinuation of Therapy.International journal of breast cancer · 2026Review
- Development of a behavioural theory-based New Medicine Service toolkit for community pharmacists to promote medication adherence.International journal of clinical pharmacy · 2025Article
- Rationale and design of the IMProving Adherence to medications for breast Cancer and cardiovascular disease equiTably (IMPACT) randomized clinical trial.Contemporary clinical trials · 2025Article
- Exercise May Improve Completion of Standard and Emerging Cancer Treatments.Exercise and sport sciences reviews · 2025Review
- Use of a Smartphone Application to Promote Adherence to Oral Medications in Patients With Breast Cancer.JCO oncology practice · 2025Article
- Engaging survivor and oncologist stakeholders to develop a patient-reported outcome assessment to use as a component of survivorship care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Active symptom monitoring for premenopausal women with breast cancer initiating adjuvant endocrine therapy: Protocol for the SWOG S2010 randomized controlled efficacy trial.Contemporary clinical trials · 2024Article
- A Behavioral Economic Examination of Sexual Behaviors in the Era of Pre-exposure Prophylaxis via Explanatory Sequential Mixed Methods.Archives of sexual behavior · 2024Article
- Home-based cognitive bias modification training for reducing maladaptive fear in patients with suspected acute coronary syndrome: a pilot randomized clinical trial.Pilot and feasibility studies · 2024Article
- Article
- Protocol for a multi-site randomised controlled feasibility study investigating intermittently scanned blood continuous glucose monitoring use for gestational diabetes: the RECOGNISE study.Pilot and feasibility studies · 2023Article
- Leveraging Electronic Health Record Technology and Team Care to Address Medication Adherence: Protocol for a Cluster Randomized Controlled Trial.JMIR research protocols · 2023Article
- Self-reported adherence and reasons for nonadherence among patients with low proportion of days covered for antihypertension medications.Journal of managed care & specialty pharmacy · 2023Article
- Mind Your Heart-II: Protocol for a behavioral randomized controlled trial of mindfulness training to promote self-care in patients with comorbid heart failure and cognitive impairment.Contemporary clinical trials · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundNonadherence to direct-acting agents (DAAs) for hepatitis C (HCV) decreases viral response. To measure nonadherence to DAAs, a reliable, valid, and easily implemented method is needed.
aimsThe goals of this study were to refine a previously validated (in patients with hypertension) self-report measure of extent of nonadherence and reasons for nonadherence in the context of DAAs and to obtain initial evidence of content validity and reliability.
methodsPhase I involved two focus groups with patients with HCV (n = 12) and one focus group with prescribers of HCV medications (n = 6) to establish content validity of reasons for nonadherence. Subsequent cognitive interviews with patients (n = 11) were conducted to refine items. Phase II was a prospective cohort study involving weekly administration of the refined measure by telephone to patients (n = 75) who are prescribed DAAs to evaluate reliability and consistency with viral response.
resultsIn the cohort study, internal consistency ranged from acceptable (α = .69) to very high (α = 1.00) across time points and was quite high on average (α = .91). Across the 75 participants, there were 895 measurement occasions; of those, nonadherence was reported on only 27 occasions (3%), all of which occurred in the first 12 weeks. These 27 occasions represented 19 (26%) different individuals. At 12 weeks, 1 (1%) of patients had a detectable HCV viral load; at 12-24 weeks posttreatment, 4 (5%) had a sustained viral response. Nonadherent patients reported an average of 1.41 reasons for nonadherence.
conclusionsThis multi-method study established content validity of reasons for nonadherence and reliability of extent of nonadherence. High rates of adherence and viral response were consistent with previous studies using other nonadherence measurement methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.