Evidence map›Paper›PMID 31037564›Full record

ArticleAMB Express2019

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline.

Carla Janaina Rebouças Marques do Rosário, Cláudia Quintino da Rocha, Daniel Moura de Aguiar, Cristian Alex Aquino Lima, Daniella Patrícia Brandão Silveira, José Antônio Costa Leite, Denise Fernandes Coutinho, Ferdinan Almeida Melo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AMB Express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 17 citations in OpenAlex.

  1. Medicinal Effect,Scientifica · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Carla Janaina Rebouças Marques do RosárioLaboratory of Immunodiagnosis, State University of Maranhão, São Luís, MA, Brazil.
Cláudia Quintino da RochaLaboratory of Advanced Studies in Phytomedicines, Department of Chemistry, Center for Exact Sciences and Technology, Federal University of Maranhão, São Luís, MA, Brazil.
Daniel Moura de AguiarLaboratory of Virology and Rickettsioses, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiabá, MT, Brazil.
Cristian Alex Aquino LimaLaboratory of Immunodiagnosis, State University of Maranhão, São Luís, MA, Brazil.
Daniella Patrícia Brandão SilveiraLaboratory of Pharmacognosy II, Department of Pharmacy, Federal University of Maranhão, São Luís, MA, Brazil.
José Antônio Costa LeiteLaboratory of Pharmacognosy II, Department of Pharmacy, Federal University of Maranhão, São Luís, MA, Brazil.
Denise Fernandes CoutinhoLaboratory of Pharmacognosy II, Department of Pharmacy, Federal University of Maranhão, São Luís, MA, Brazil.
Ferdinan Almeida MeloLaboratory of Immunodiagnosis, State University of Maranhão, São Luís, MA, Brazil. ferdinanalmeida.uema@gmail.com.ORCID http://orcid.org/0000-0001-6111-3672
Universidade Estadual do Maranhão · BRUniversidade Federal do Maranhão · BRExact Sciences (United States) · USUniversidade Federal de Mato Grosso · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine Monocytic Ehrlichiosis (CME) is an infectious disease caused by the rickettsia organism Ehrlichia canis which is transmitted mainly the ixodid brown dog tick Rhipicephalus sanguineus. The prevalence of E. canis infection has been increasing in recent years. The World Health Organization has been warned about antibiotics resistance and one of the way to prevent this situation is found new compound with this property. Doxycycline is the treatment of choice for this tick-borne disease. Adverse effects are noted in dogs that are sensitive to this drug. Antibiotic resistance may also occur. The present study aimed to evaluate the anti-Ehrlichia properties of the essential oil of the aerial parts of Ageratum conyzoides L. in infected DH82 cells, as well as its anti-Ehrlichia activity associated with doxycycline using the checkerboard assay. A. conyzoides is a native plant from northeast Brazil with many reports of ethnopharmacological applications. The essential oil of A. conyzoides was extracted from the aerial parts of the plant using the hydrodistillation method. E. canis-infected DH82 cells were cultured in DMEM (Dulbecco's Modified Eagle Medium), maintained at 37 °C and 5% CO

Indexed as

Alternative treatment (alternative therapy)AssociationDH82 cellsMentrasto (Ageratum conyzoides, billygoat-weed)Precocene I

Identifiers

PMID31037564
PMCPMC6488629
OpenAlexW2946984411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.