Evidence map›Paper›PMID 31037556›Full record

ArticleMetabolic brain disease2019

Magnesium sulfate protects blood-brain barrier integrity and reduces brain edema after acute ischemic stroke in rats.

Javad Shadman, Nooshin Sadeghian, Alireza Moradi, Shahab Bohlooli, Hamdollah Panahpour

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Potential role ofCurrent molecular medicine · 2024
    Review
  7. Magnesium (MgCurrent pharmaceutical design · 2024
    Review
  8. Article
  9. Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Roles of Nitric Oxide in Brain Ischemia and Reperfusion.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Magnesium Increases the Protective Effect of Citicoline on Aluminum Chloride-induced Cognitive Impairment.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020
    Article
  16. Article
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Javad ShadmanDepartment of Physiology, Medical School, Ardabil University of Medical Sciences, Ardabil, 56197, Iran.
Nooshin SadeghianDepartment of Physiology, Medical School, Ardabil University of Medical Sciences, Ardabil, 56197, Iran.
Alireza MoradiDepartment of Physiology, Medical School, Ardabil University of Medical Sciences, Ardabil, 56197, Iran.
Shahab BohlooliDepartment of Pharmacology, Pharmacy School, Ardabil University of Medical Sciences, Ardabil, Iran.
Hamdollah PanahpourDepartment of Physiology, Medical School, Ardabil University of Medical Sciences, Ardabil, 56197, Iran. panahpour.h@gmail.com.ORCID 0000-0002-3315-7624
Ardabil University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain edema is a fatal complication of acute ischemic stroke and associated with worse outcomes in patients. This study was designed to evaluate the effects of magnesium sulfate on vasogenic brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia-reperfusion (IR) in a rat model of ischemic stroke. A total of 72 male Sprague-Dawley rats were categorized into the following three primary groups: sham, control ischemic, magnesium-sulfate-treated (300 mg/kg loading dose, followed by an additional 100 mg/kg) ischemic (n = 24 in each group). Transient focal cerebral ischemia was induced by 60-min-long occlusion of the left middle cerebral artery, followed by 24-h-long reperfusion. Sensorimotor deficits, infarct volume, and brain edema were evaluated at the end of the reperfusion period. The BBB permeability was assessed by Evans Blue extravasation technique. Lipid peroxidation levels were assessed by measuring the malondialdehyde content in the brain tissue homogenate, and the activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were detected according to the technical manual of the assay kits. Induction of cerebral ischemia in the control group produced considerable BBB damage in conjunction with severe brain edema formation. Treatment with magnesium sulfate significantly attenuated brain edema and protected BBB integrity in the ischemic lesioned hemisphere. In addition, magnesium sulfate reduced lipid peroxidation and increased antioxidant protection of brain tissue by upregulating the activities of antioxidant enzymes. Treatment with magnesium sulfate protected BBB integrity against IR-induced damage and reduced vasogenic edema formation partly via antioxidant mechanisms in a rat model of acute ischemic stroke.

Indexed as

AnimalsBlood-Brain BarrierBrainBrain EdemaBrain IschemiaCatalaseDisease Models, AnimalGlutathione PeroxidaseLipid PeroxidationMagnesium SulfateMaleMalondialdehydeNeuroprotective AgentsPermeabilityRatsRats, Sprague-DawleyCatalaseGlutathione PeroxidaseMagnesium SulfateMalondialdehydeNeuroprotective AgentsSuperoxide DismutaseBrain edemaCatalaseMagnesium sulfateMalondialdehydeStrokeSuperoxide dismutase

Identifiers

PMID31037556
OpenAlexW2943635701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.