Evidence map›Paper›PMID 31037494›Full record

ReviewMikrochimica acta2019

Magnetic nanoparticles for smart electrochemical immunoassays: a review on recent developments.

Matěj Pastucha, Zdeněk Farka, Karel Lacina, Zuzana Mikušová, Petr Skládal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. MoSDiagnostics (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Giant Magnetoresistance Biosensors in Biomedical Applications.ACS applied materials & interfaces · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Recombinant antibodies and their use for food immunoanalysis.Analytical and bioanalytical chemistry · 2022
    Review
  17. Structural and Magnetic Properties of CoNanomaterials (Basel, Switzerland) · 2021
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matěj PastuchaDepartment of Biochemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Zdeněk FarkaCentral European Institute of Technology, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Karel LacinaCentral European Institute of Technology, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Zuzana MikušováDepartment of Biochemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Petr SkládalDepartment of Biochemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. skladal@chemi.muni.cz.ORCID 0000-0002-3868-5725

Funding

Masarykova Univerzita MUNI/A/1100/2017Ministerstvo Školství, Mládeže a Tělovýchovy LQ1601
6 · The paper itself

Abstract

This review (with 129 refs) summarizes the progress in electrochemical immunoassays combined with magnetic particles that was made in the past 5 years. The specifity of antibodies linked to electrochemical transduction (by amperometry, voltammetry, impedimetry or electrochemiluminescence) gains further attractive features by introducing magnetic nanoparticles (MNPs). This enables fairly easy preconcentration of analytes, minimizes matrix effects, and introduces an appropriate label. Following an introduction into the fundamentals of electrochemical immunoassays and on nanomaterials for respective uses, a large chapter addresses method for magnetic capture and preconcentration of analytes. A next chapter discusses commonly used labels such as dots, enzymes, metal and metal oxide nanoparticles and combined clusters. The large field of hybrid nanomaterials for use in such immunoassays is discussed next, with a focus on MNPs composites with various kinds of graphene variants, polydopamine, noble metal nanoparticles or nanotubes. Typical applications address clinical markers (mainly blood and urine parameters), diagnosis of cancer (markers and cells), detection of pathogens (with subsections on viruses and bacteria), and environmental and food contaminants as toxic agents and pesticides. A concluding section summarizes the present status, current challenges, and highlights future trends. Graphical abstract Magnetic nanoparticles (MNP) with antibodies (Ab) capture and preconcentrate analyte from sample (a) and afterwards become magnetically (b) or immunospecifically (c) bound at an electrode. Signal either increases due to the presence of alabel (b) or decreases as the redox probe is blocked (c).

Indexed as

AnimalsElectrochemistryHumansImmunoassayMagnetsNanoparticlesBioconjugationImmunosensorPreconcentrationScreen printed electrodes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.