Evidence map›Paper›PMID 31037416›Full record

ArticleJournal of neurology2019

Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatal

Nicolas Nicastro, Jennifer Wegrzyk, Maria Giulia Preti, Vanessa Fleury, Dimitri Van de Ville, Valentina Garibotto, Pierre R Burkhard

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Imaging of dopamine transporters in Parkinson disease: a meta-analysis ofAnnals of clinical and translational neurology · 2020
    Pooled it
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  13. Artificial intelligence for molecular neuroimaging.Annals of translational medicine · 2021
    Review
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  15. Article
  16. Appropriate assessment method ofJournal of neurology · 2020
    Article
  17. A Shape Approximation for Medical Imaging Data.Sensors (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Nicolas NicastroDepartment of Psychiatry, University of Cambridge, Hills Road, Cambridge, CB2 0SP, UK. nn311@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-5836-0792
Jennifer WegrzykDivision of Neurology, Geneva University Hospitals, Geneva, Switzerland.
Maria Giulia PretiCenter for Neuroprosthetics, Institute of Bioengineering, EPFL, Lausanne, Switzerland.
Vanessa FleuryDivision of Neurology, Geneva University Hospitals, Geneva, Switzerland.
Dimitri Van de VilleCenter for Neuroprosthetics, Institute of Bioengineering, EPFL, Lausanne, Switzerland.
Valentina GaribottoDivision of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.
Pierre R BurkhardDivision of Neurology, Geneva University Hospitals, Geneva, Switzerland.
University Hospital of Geneva · CHUniversity of Cambridge · GB

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030_169876Velux Stiftung 1123
6 · The paper itself

Abstract

objectivesTo provide an automated classification method for degenerative parkinsonian syndromes (PS) based on semiquantitative

methods

resultsUnivariate analyses showed significantly lower VOIs uptake, higher striatal AI and C/P ratio for each PS in comparison to controls (all p < 0.001). Among PS, higher degree of striatal impairment was observed in MSA-P and PSP, while CBS showed moderate uptake reduction and higher AI. Binary SVM classification showed 92.9% accuracy in distinguishing PS from controls. Classification based on each binary combination of PS ranged 62.9-83.7% accuracy with the most satisfactory results when separating CBS from the other PS. Sensitivity and specificity values were high and balanced ranging from 60 to 80% for all analyses with > 70% accuracy. Overall, striatal AI and C/P ratio on the more affected side had the highest weighting factors.

conclusionSemiquantitative

Indexed as

Iodine RadioisotopesSupport Vector MachineAdultAgedAged, 80 and overCorpus StriatumFemaleHumansMaleMiddle AgedParkinsonian DisordersRetrospective StudiesTomography, Emission-Computed, Single-PhotonIodine RadioisotopesClassificationDegenerative parkinsonismParkinson’s diseaseSPECT

Identifiers

PMID31037416
PMCPMC6586917
OpenAlexW2943448780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.