Evidence map›Paper›PMID 31037410›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2020

Time-pattern of adverse outcomes after an infection-triggered acute heart failure decompensation and the influence of early antibiotic administration and hospitalisation: results of the PAPRICA-3 study.

Òscar Miró, Koji Takagi, Étienne Gayat, Víctor Gil, Pere Llorens, Francisco J Martín-Sánchez, Javier Jacob, Pablo Herrero-Puente, Rosa Escoda, María Pilar López-Díez and 13 more

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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Management of Acute Heart Failure during an Early Phase.International journal of heart failure · 2020
    Review
  7. Acute heart failure.Nature reviews. Disease primers · 2020 · on this map
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 19 institutions in 4 countries.

Òscar MiróEmergency Department, Hospital Clinic, Institutd'InvestigacióBiomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain. omiro@clinic.cat.
Koji TakagiGREAT Network, Rome, Italy.
Étienne GayatINSERM UMR-S 942, Paris, France.
Víctor GilEmergency Department, Hospital Clinic, Institutd'InvestigacióBiomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain.
Pere LlorensEmergency Department, Short-Stay Unit and Home Hospitalization, Hospital General de Alicante, Alicante, Spain.
Francisco J Martín-SánchezEmergency Department, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
Javier JacobEmergency Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Catalonia, Spain.
Pablo Herrero-PuenteEmergency Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Rosa EscodaEmergency Department, Hospital Clinic, Institutd'InvestigacióBiomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain.
María Pilar López-DíezEmergency Department, Hospital Universitario de Burgos, Burgos, Spain.
Amparo ValeroEmergency Department, Hospital Doctor Peset, Valencia, Spain.
Marta FuentesEmergency Department, Hospital Universitario de Salamanca, Salamanca, Spain.
José M GarridoEmergency Department, Hospital Virgen de La Macarena, Sevilla, Spain.
Eva SalvoEmergency Department, Hospital Universitario La Fe, Valencia, Spain.
Miguel A RizziEmergency Department, Hospital de La Santa CreuiSant Pau, Barcelona, Catalonia, Spain.
Alfons AguirreEmergency Department, Hospital del Mar, Barcelona, Catalonia, Spain.
Lissete Travería BécquerEmergency Department, Hospital Universitario de Canarias, Tenerife, Spain.
Alberto Domínguez-RodríguezCardiology Department, Hospital Universitario de Canarias, Tenerife, Spain.
Joan PadrosaEmergency Department, Hospital Clinic, Institutd'InvestigacióBiomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain.
Gemma MartínezEmergency Department, Hospital Clinic, Institutd'InvestigacióBiomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain.
Mattia ArrigoGREAT Network, Rome, Italy.
Yonathan FreundEmergency Department, Hopital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
Alexandre MebazaaGREAT Network, Rome, Italy.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Universitario de Canarias · ESUniversitat de Barcelona · ESAssistance Publique – Hôpitaux de Paris · FRBellvitge University Hospital · ESComplejo Hospitalario de Salamanca · ESHospital Clínico San Carlos · ESHospital Del Mar · ESHospital de Sant Pau · ESHospital General Universitario de Alicante Doctor Balmis · ESHospital Universitari i Politècnic La Fe · ESHospital Universitario Central de Asturias · ESHospital Universitario de Burgos · ESHospital Universitario Doctor Peset · ESHospital Universitario Virgen Macarena · ESNippon Medical School Musashi Kosugi Hospital · JPSorbonne Université · FRUniversité Paris Cité · FRUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether patients with an acute heart failure (AHF) episode triggered by infection present different outcomes compared to patients with no trigger and the effects of early antibiotic administration (EAA) and hospitalisation.

methodsTwo groups were made according to the AHF trigger: infection (G1) or none identified (G2). The primary outcome was 13-week (91-days) all-cause mortality, and secondary outcomes were 13-week post-discharge mortality, readmission or combined endpoint. Comparisons are presented as unadjusted and adjusted (MEESSI risk score) hazard ratios (uHR/aHR) for G1 compared to G2 patients, also estimated by weeks. Stratified analysis by EAA (provided/not provided) and patient disposition (discharged/hospitalised) was performed.

resultsWe included 6727 patients (G1 = 3973; G2 = 2754). The 13-week mortality uHR was 1.11 (0.99-1.25; p = 0.06; with significant increases in the first 3 weeks), and the aHR was 0.91 (0.81-1.02; p = 0.11). There were no differences in unadjusted secondary post-discharge outcomes; however, G1 outcomes significantly improved after adjustment: aHR 0.83 (0.71-0.96; p = 0.01) for mortality, 0.92 (0.84-0.99; p = 0.04) for readmission, and 0.92 (0.85-0.99; p = 0.04) for the combined endpoint. We found a differentiated effect of hospitalisation (p < 0.05 for interaction; better post-discharge readmission and combined outcomes in G1), and a trend (p = 0.06) to lower mortality in G1 patients with EAA. Additionally, there were some differences between groups in baseline and acute episode characteristics.

conclusionAHF triggered by infection is not associated with a higher mid-term mortality and has better post-discharge outcomes; however, the first 3 weeks are an extremely vulnerable period. Since hospitalisation could have a role in limiting adverse post-discharge events, and EAA in reducing mortality, these relationships should be prospectively explored in further studies.

Indexed as

Acute DiseaseAgedAged, 80 and overAnti-Bacterial AgentsFemaleHeart FailureHospitalizationHumansInfectionsMalePatient DischargePatient ReadmissionRegistriesTime FactorsAnti-Bacterial AgentsAcute heart failureInfeccionMortalityOutcomesTrigger

Identifiers

PMID31037410
OpenAlexW2943346791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.