Evidence map›Paper›PMID 31037351›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2019

Automatic image segmentation based on synthetic tissue model for delineating organs at risk in spinal metastasis treatment planning.

Olaf Wittenstein, Patrick Hiepe, Lars Henrik Sowa, Elias Karsten, Iris Fandrich, Juergen Dunst

Abstract read
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olaf WittensteinDepartment of Radiation Oncology, Universitätsklinikum Schleswig-Holstein Campus Kiel, Arnold-Heller-Straße 3, Haus 50, 24105, Kiel, Germany. olaf.wittenstein@uksh.de.ORCID http://orcid.org/0000-0003-4127-3139
Patrick HiepeR&D Anatomical Mapping, Brainlab AG, Olof-Palme-Straße 9, 81829, Munich, Germany.
Lars Henrik SowaR&D Anatomical Mapping, Brainlab AG, Olof-Palme-Straße 9, 81829, Munich, Germany.
Elias KarstenDepartment of Radiation Oncology, Universitätsklinikum Schleswig-Holstein Campus Kiel, Arnold-Heller-Straße 3, Haus 50, 24105, Kiel, Germany.
Iris FandrichDepartment of Radiation Oncology, Universitätsklinikum Schleswig-Holstein Campus Kiel, Arnold-Heller-Straße 3, Haus 50, 24105, Kiel, Germany.
Juergen DunstDepartment of Radiation Oncology, Universitätsklinikum Schleswig-Holstein Campus Kiel, Arnold-Heller-Straße 3, Haus 50, 24105, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOne of the main goals in software solutions for treatment planning is to automatize delineation of organs at risk (OARs). In this pilot feasibility study a clinical validation was made of computed tomography (CT)-based extracranial auto-segmentation (AS) using the Brainlab Anatomical Mapping tool (AM).

methodsThe delineation of nine extracranial OARs (lungs, kidneys, trachea, heart, liver, spinal cord, esophagus) from clinical datasets of 24 treated patients was retrospectively evaluated. Manual delineation of OARs was conducted in clinical routine and compared with AS datasets using AM. The Dice similarity coefficient (DSC) and maximum Hausdorff distance (HD) were used as statistical and geometrical measurements, respectively. Additionally, all AS structures were validated using a subjective qualitative scoring system.

resultsAll patient datasets investigated were successfully processed with the evaluated AS software. For the left lung (0.97 ± 0.03), right lung (0.97 ± 0.05), left kidney (0.91 ± 0.07), and trachea (0.93 ± 0.04), the DSC was high with low variability. The DSC scores of other organs (right kidney, heart, liver, spinal cord), except the esophagus, ranged between 0.7 and 0.9. The calculated HD values yielded comparable results. Qualitative assessment showed a general acceptance in more than 85% of AS OARs-except for the esophagus.

conclusionsThe Brainlab AM software is ready for clinical use in most of the OARs evaluated in the thoracic and abdominal region. The software generates highly conformal structure sets compared to manual contouring. The current study design needs revision for further research.

Indexed as

AlgorithmsModels, AnatomicAbdomenFeasibility StudiesHumansImage Processing, Computer-AssistedOrgans at RiskPilot ProjectsRadiotherapy Planning, Computer-AssistedSoftware DesignSpinal NeoplasmsThoraxTomography, X-Ray ComputedAtlasAutomizationElementsExtra-cranialRadiotherapy

Identifiers

PMID31037351
PMCPMC6868111

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.