Trial reportClinical oral investigations2020
Randomised clinical trial investigating self-assembling peptide P
Trial report in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04933331 (An Observational Multi-cite Study to Evaluate and Compare the Effectiveness of Various Tooth Specific Treatments in the Management of Early Caries Lesions), which is not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Observational Multi-cite Study to Evaluate and Compare the Effectiveness of Various Tooth Specific Treatments in the Management of Early Caries Lesions
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Self-assembling peptides for managing white spot lesions: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Pooled it
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- Nonrestorative Caries Treatment: A Systematic Review Update.International dental journal · 2022Pooled it
- Evaluation of the remineralization potential of self-assembling peptide P11-4 with fluoride compared to fluoride varnish in the management of incipient carious lesions: a randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: randomized controlled clinical trial.BMC oral health · 2023Trial
- Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial.Clinical oral investigations · 2023Trial
- Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2021Trial
- Efficacy of PScientific reports · 2020Trial
- Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets.Scientific reports · 2020Trial
- Effect of self-assembling peptide PScientific reports · 2020Trial
- Randomized Clinical Trial investigating Self-Assembling Peptide PScientific reports · 2020Trial
- Remineralization of Initial Carious Lesions Using Peptides: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2026Review
- Evaluating the combined effect of a biomimetic organic matrix and bioinspired fluorapatite nanoparticles on initial caries lesions.RSC advances · 2026Article
- Comparison of the effect of self-assembling peptide PBMC oral health · 2026Article
- Non-Operative, Micro- and Minimally Invasive Methods for Caries Treatment-A Narrative Review.Journal of clinical medicine · 2026Review
- Effect of diode laser on self-assembling peptide enamel remineralization -Bioinformation · 2026Article
- Review
- Article
- Evaluation of the efficacy of P11-4 and CCP-ACPF in the prevention and treatment of white spot lesions: a multi-technique approach.Scientific reports · 2025Article
- The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis prospective, randomised, split-mouth, clinical trial compared the efficacy of the self-assembling peptide P MATERIALS AND
methodsSubjects presenting at least two clinically affected teeth were treated at D0 (day 0) and D90 with P
resultsOverall, 37 subjects (13-36 years) with 90 early carious lesions were included. HLM analysis showed a significant difference between test and control groups, indicating a decrease in test lesions and stabilisation of control lesions size (p = 0.001). The test lesion's mean size (SD) relative to baseline decreased to D30 = 0.936(0.127), D90 = 0.874(0.173), D180 = 0.844(0.215) and D360 = 0.862(0.352), whereas control lesions remained stable at D30 = 1.018(0.209), D90 = 1.013(0.207), D180 = 1.029(0.235) and D360 = 1.068(0.401). The effect sizes ranged from 0.47 to 0.82.
conclusionsWithin the limits of this study, it was shown that the size of early carious lesions treated with P CLINICAL RELEVANCE: The self-assembling peptide P
Indexed as
Identifiers
31037343What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.