ArticleCurrent developments in nutrition2019
Dietary Protein and Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Heart Study Offspring Cohort.
Article in Current developments in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Impact of Quantity and Type of Dietary Protein on Cardiovascular Disease Risk Factors Using Standard and Network Meta-analyses of Randomized Controlled Trials.Nutrition reviews · 2025Pooled it
- Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis.Inflammopharmacology · 2025Pooled it
- Influence of Plant and Animal Proteins on Inflammation Markers among Adults with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Effects of a chickpea protein hydrolysate on exercise-induced biomarkers of muscle damage and inflammation in federated road cyclists.Journal of the International Society of Sports Nutrition · 2026Trial
- Trial
- Partially Replacing Dietary Carbohydrate With Unsaturated Fat or Protein Shifts Protein-Based HDL Subspecies Toward Lower Coronary Heart Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Trial
- Impact of Dairy Intake on Plasma FNutrients · 2021Trial
- Trial
- Association of dietary oxidative balance score, dietary inflammatory potential and fractures among adults aged ≥ 40 years in the United States in 1999-2018.Asia Pacific journal of clinical nutrition · 2026Article
- Dietary protein, major dietary protein sources, and chronic joint diseases risk.Nutrition & metabolism · 2026Article
- Pearl Millet-A Forgotten Ancient Grain with Emerging Immunomodulatory Potential in Sports Nutrition.Current nutrition reports · 2026Review
- Review
- Therapeutic perspective on cardiomyopathy and heart failure in older adults through the lens of chronic inflammation.Vascular pharmacology · 2026Article
- From molecular mechanisms to nutritional applications: protein and polyphenol interventions in sarcopenia.Journal of physiology and biochemistry · 2026Review
- Dietary protein intake in relation to metabolic syndrome reversion: findings from the Tehran lipid and glucose study.Scientific reports · 2026Article
- SPORT: A Novel Biopsychosocial Framework for Chronic Low Back Pain in a Young Athlete - A Case Report.International journal of sports physical therapy · 2026Article
- Dietary protein intake, inflammatory biomarkers, genetic susceptibility, and the incidence of sarcopenia: a prospective population-based study.Frontiers in nutrition · 2026Article
- The association between dietary consumption of amino acids and the risk of non-alcoholic fatty liver disease: a case-control study.Nutrition & metabolism · 2025Article
- Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies.European journal of epidemiology · 2025Article
- Low-Carbohydrate Diet Patterns That Favor High-Quality Carbohydrates Are Associated with Beneficial Long-Term Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Offspring Cohort.Current developments in nutrition · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic inflammation is thought to be a major characteristic of aging, which may increase need for substrates, specifically protein, to support anti-inflammatory processes.
objectivesThe aim of this study was to assess associations between dietary protein and changes in biomarkers of inflammation and oxidative stress over the long term in a community-dwelling population.
methodsIn 2061 participants of the Framingham Heart Study Offspring cohort who attended exams 7 (1998-2001; mean ± SD age 60.0 ± 8.8 y, 56% female) and 8 (2005-2008), total, animal, and plant protein intakes were assessed by food-frequency questionnaire at each exam, energy adjusted, and averaged. We defined an inflammation and oxidative stress score as the sum of rank-normalized values of 9 circulating biomarkers (C-reactive protein, osteoprotegerin, P-selectin, tumor necrosis factor receptor II, soluble intercellular adhesion molecule-1, interleukin 6, monocyte chemoattractant protein 1, and lipoprotein phospholipase A2 mass and activity), and urinary isoprostanes, along with 2 subscores. Adjusted least-square means of changes in the scores and log individual biomarkers in quartile categories of intake were estimated with the use of linear regression models, across mean ± SD 6.6 ± 0.7 y of follow-up.
resultsProtein intake was inversely associated with changes in the inflammation and oxidative stress score (mean ± SE in Q1 compared with Q4: 0.77 ± 0.17 compared with 0.31 ± 0.19;
conclusionsDietary protein, particularly from plant sources, may be associated with beneficial changes in the inflammatory burden in aging populations.
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