Evidence map›Paper›PMID 31037218›Full record

ArticleJournal of nutritional science2019

Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut-liver axis.

Paola Vitaglione, Giovanna Mazzone, Vincenzo Lembo, Giuseppe D'Argenio, Antonella Rossi, Maria Guido, Marcella Savoia, Federico Salomone, Ilario Mennella, Francesca De Filippis and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nutritional science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Coffee and Microbiota: A Narrative Review.Current issues in molecular biology · 2024
    Review
  10. Article
  11. Review
  12. Intestinal Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease.Journal of clinical and translational hepatology · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Paola VitaglioneDepartment of Agricultural Sciences, University of Naples 'Federico II', Portici, Italy.
Giovanna MazzoneDepartment of Clinical Medicine and Surgery, Gastroenterology Unit, University of Naples 'Federico II', Naples, Italy.
Vincenzo LemboDepartment of Clinical Medicine and Surgery, Gastroenterology Unit, University of Naples 'Federico II', Naples, Italy.
Giuseppe D'ArgenioDepartment of Clinical Medicine and Surgery, Gastroenterology Unit, University of Naples 'Federico II', Naples, Italy.
Antonella RossiDepartment of Clinical Medicine and Surgery, Gastroenterology Unit, University of Naples 'Federico II', Naples, Italy.
Maria GuidoDepartment of Medicine, University of Padua, Padua, Italy.
Marcella SavoiaDepartment of Biochemistry and Medical Biotechnology, University of Naples 'Federico II', Naples, Italy.
Federico SalomoneDivision of Gastroenterology, Azienda Sanitaria Provinciale di Catania, Catania, Italy.
Ilario MennellaDepartment of Agricultural Sciences, University of Naples 'Federico II', Portici, Italy.
Francesca De FilippisDepartment of Agricultural Sciences, University of Naples 'Federico II', Portici, Italy.
Danilo ErcoliniDepartment of Agricultural Sciences, University of Naples 'Federico II', Portici, Italy.
Nicola CaporasoTask Force on Microbiome Studies, University of Naples 'Federico II', Naples, Italy.
Filomena MoriscoTask Force on Microbiome Studies, University of Naples 'Federico II', Naples, Italy.
University of Naples Federico II · ITFederico II University Hospital · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coffee consumption is inversely associated with the risk of non-alcoholic fatty liver disease (NAFLD). A gap in the literature still exists concerning the intestinal mechanisms that are involved in the protective effect of coffee consumption towards NAFLD. In this study, twenty-four C57BL/6J mice were divided into three groups each receiving a standard diet, a high-fat diet (HFD) or an HFD plus decaffeinated coffee (HFD+COFFEE) for 12 weeks. Coffee supplementation reduced HFD-induced liver macrovesicular steatosis (

Indexed as

Acyl-CoA OxidaseAlanine TransaminaseAlcaligenaceaeAnimalsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1Blood GlucoseCholesterolClaudinsCoffeeDietary SupplementsDiet, High-FatFecesGastrointestinal MicrobiomeHaptoglobinsIntestinesAbca1 protein, mouseAcyl-CoA OxidaseAlanine TransaminaseATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1Blood GlucoseCholesterolClaudinsCoffeeHaptoglobinsPolyphenolsPPAR alphaProtein PrecursorsRNA, MessengerzonulinABCA1, ATP-binding cassette subfamily A1ABCG1, ATP-binding cassette subfamily G1ACOX1, acyl-CoA oxidase 1ALT, alanine aminotransferaseFFAR, free fatty acid receptorGut microbiotaGut permeabilityHFD+COFFEE, HFD plus decaffeinated coffeeHFD, high-fat dietLXR-α, liver X receptor-αMetabolic syndromeNAFLD, non-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisPolyphenolsPYY, peptide YYSD, standard dietZO-1, zonulin-1

Identifiers

PMID31037218
PMCPMC6477661
OpenAlexW2942278269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.