ArticleThe Pan African medical journal2018
[Hepatitis B and renal failure: prevalence and associated factors in National University Hospital Center of Cotonou].
Article in The Pan African medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Article
- Screening for renal impairment in viral hepatopathy B: it is time to begin.Future science OA · 2023Article
- Deficiency, incapacity and social disadvantage of patients with chronic hepatitis B: a case-control study.La Tunisie medicaleArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
introductionthe association between the kidneys and hepatitis B is complex. This study aims to determine the prevalence and factors associated with renal disease in people living with hepatitis B virus (PLHBV) in Cotonou.
methodswe conducted a cross-sectional, descriptive and analytical study in the Hepatogastroenterology Department at the National University Hospital Center in Cotonou over the period May -August 2017. All the patients with positive hepatitis B surface antigen (HBS Ag) test hospitalized in the study period were included. The diagnosis of renal failure was retained in patients with glomerular filtration rate less than 90 mL/min/1.73 m
resultsthe study involved 105 patients with positive hepatitis B surface antigen (HBS Ag) test Among them, 65 (61.9%) were under anti-HBV treatment ( 62 of them were under tenofovir ); 41 patients had renal failure (39%) with tubular involvement (2 cases) and glomerular involvement (4 cases). Renal function had got progressively worse over time in 22 patients (21%) and had improved in 6 patients (5.7%). Univariate analysis showed that factors associated with the occurrence of renal failure were: age greater than 50 years (p = 0.0125), high blood pressure (p = 0.0037), initially abnormal renal function (p < 0.0003) and co-medications (p = 0.0007). Anti-HBV treatment wasn't associated with the occurrence of renal failure (p = 0.2887).
conclusionthe prevalence of renal failure in PLHBV was high (39%). Age, arterial hypertension, pre-existing renal failure and co-medications were identified as factors associated with decline in renal function in PLHBV.
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