Evidence map›Paper›PMID 31037141›Full record

ArticleTheranostics2019

Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-κB Pathway.

Qing Yuan, Fuping Gao, Yawen Yao, Pengju Cai, Xiangchun Zhang, Jinling Yuan, Kaixiao Hou, Liang Gao, Xiaojun Ren, Xueyun Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Qing YuanDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Fuping GaoCAS Key Laboratory for the Biological Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Yawen YaoDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Pengju CaiCAS Key Laboratory for the Biological Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Xiangchun ZhangCAS Key Laboratory for the Biological Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Jinling YuanDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Kaixiao HouDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Liang GaoDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Xiaojun RenDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Xueyun GaoDepartment of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Beijing University of Technology · CNInstitute of High Energy Physics · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation-induced bone erosion is a major pathological factor in several chronic inflammatory diseases that often cause severe outcomes, such as rheumatoid arthritis and periodontitis. Plenty of evidences indicated that the inflammatory bone destruction was attributed to an increase in the number of bone-resorbing osteoclasts. However, anti-resorptive therapy alone failed to prevent bone loss in an inflammatory condition. Conventional anti-inflammation treatments are usually intended to suppress inflammation only, but ignore debilitating the subsequent bone destruction. Therefore, inhibition of proinflammatory activation of osteoclastogenesis could be an important strategy for the development of drugs aimed at preventing inflammatory bone destruction.

Indexed as

AnimalsBone ResorptionCell DifferentiationCell LineGoldInflammationMacrophagesMaleMiceNF-kappa BOsteoclastsOsteogenesisRANK LigandRAW 264.7 CellsSignal TransductionGoldNF-kappa BRANK Ligandgold clusterinflammatory bone destructionNF-κB pathwayosteoclastogenesis

Identifiers

PMID31037141
PMCPMC6485295
OpenAlexW2924830902

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.