ArticleScientific reports2019
Bruch's Membrane Thickness and Retinal Pigment Epithelium Cell Density in Experimental Axial Elongation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Safety and pharmacokinetics of intravitreally repeatedly injected panitumumab in non-human primates - a study performed under good laboratory practice.BMC ophthalmology · 2026Article
- Role of bruch's membrane opening area: a clinical indicator of the progression of macular defects in high myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Assessing the Validity of the Fellow Eye as an Internal Control in Early-Phase Clinical Trials for Myopic Chorioretinal Atrophy.Journal of clinical medicine · 2026Article
- Role of BDNF in form-deprivation myopia progression in guinea pigs.Frontiers in immunology · 2026Article
- In-vivo sclera thickness measurements in experimental myopia of guinea pigs.BMC ophthalmology · 2025Article
- The Association Between the Retinal Sequelae of Myopia and Glaucoma in a Global Cohort.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Preclinical study of novel human allogeneic adipose tissue-derived mesenchymal stem cell sheets toward a first-in-human clinical trial for myopic chorioretinal atrophy.Stem cell research & therapy · 2024Article
- Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews.Experimental eye research · 2024Article
- Structural, blood flow and functional changes in the macular area and the expression of aqueous humor factors in myopia.Frontiers in medicine · 2024Article
- IMI-Nonpathological Human Ocular Tissue Changes With Axial Myopia.Investigative ophthalmology & visual science · 2023Article
- Myopic Versus Glaucomatous Parapapillary Beta Zone in Myopic Eyes Versus Eyes With Secondary Angle-Closure Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Intravitreal Short-Hairpin RNA Attenuated Adeno-Associated Virus-Induced Knockdown of Amphiregulin and Axial Elongation in Experimental Myopia.Investigative ophthalmology & visual science · 2023Article
- Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia.Investigative ophthalmology & visual science · 2023Article
- Anatomic Peculiarities Associated with Axial Elongation of the Myopic Eye.Journal of clinical medicine · 2023Review
- Reduction of experimental ocular axial elongation by neuregulin-1 antibody.Frontiers in medicine · 2023Article
- Photoreceptor density in relation to axial length and retinal location in human eyes.Scientific reports · 2022Article
- Epiregulin, epigen and betacellulin antibodies and axial elongation in young guinea pigs with lens-induced myopization.BMC ophthalmology · 2022Article
- Intraocular Amphiregulin antibody and axial elongation in nonhuman primates.Frontiers in ophthalmology · 2022Article
- Visually guided chick ocular length and structural thickness variations assessed by swept-source optical coherence tomography.Biomedical optics express · 2021Article
- IMI 2021 Yearly Digest.Investigative ophthalmology & visual science · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess anatomical changes in eyes with progressive myopia, we morphometrically examined the eyes of guinea pigs with lens-induced axial elongation. Starting at an age of 3-4 weeks, guinea pigs in the experimental group (n = 20 animals) developed unilateral lens-induced axial elongation by wearing goggles for 5 weeks compared to a control group of 20 animals without intervention (axial length:8.91 ± 0.08 mm versus 8.74 ± 0.07 mm; P < 0.001). Five weeks after baseline, the animals were sacrificed, and the eyes enucleated. As measured histomorphometrically, Bruch's membrane thickness was not significantly correlated with axial length in either group at the ora serrata (P = 0.41), equator (P = 0.41), midpoint between equator and posterior pole (MBEPP) (P = 0.13) or posterior pole (P = 0.89). Retinal pigment epithelium (RPE) cell density decreased with longer axial length at the MBEPP (P = 0.04; regression coefficient beta = -0.33) and posterior pole (P = 0.01; beta = -0.40). Additionally, the thickness of the retina and sclera decreased with longer axial length at the MBEPP (P = 0.01; beta = -0.42 and P < 0.001; beta = -0.64, respectively) and posterior pole (P < 0.001; beta = -0.51 and P < 0.001; beta = -0.45, respectively). Choroidal thickness decreased at the posterior pole (P < 0.001; beta = -0.51). Experimental axial elongation was associated with a thinning of the retina, choroid and sclera and a decrease in RPE cell density, most markedly at the posterior pole. Bruch's membrane thickness was not related to axial elongation.
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