ArticleNature neuroscience2019
Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 159 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
159 citing papers in PubMed.
- Cerebellar Stimulation Modulates Reward Processing: A High-definition Transcranial Direct Current Stimulation Study.Cerebellum (London, England) · 2025Trial
- Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Brain-AI convergence: Generative world models and hierarchical attention for human intelligence.Patterns (New York, N.Y.) · 2026Review
- Cerebellum-inspired neural network of supervised learning with tensor-based sparse coding for multi-class classification.PLoS computational biology · 2026Article
- Representations of Subsecond Duration-Based Timing by Complex Spike Synchrony in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Unsupervised nonmotor learning in the human cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Article
- Cerebellar neural populations orchestrate dopamine reward signaling with single-trial precision.Nature communications · 2026Article
- The Human Cerebellum Encodes Temporally Sensitive Reinforcement Learning Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026Article
- Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning.bioRxiv : the preprint server for biology · 2026Article
- Random innervation of cerebellar Purkinje cells as a substrate for diverse representational learning.bioRxiv : the preprint server for biology · 2026Article
- Competitive Olivocerebellar Input Selection Promotes Resilient Circuit Formation.bioRxiv : the preprint server for biology · 2026Article
- Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.Nature neuroscience · 2026Article
- Neural circuits encode prior knowledge of temporal statistics.Nature neuroscience · 2026Article
- The cerebellum implements structured representation of valence to support adaptive behavior control.Science advances · 2026Article
- Protracted prediction: Neurodevelopment of reward processing in the adolescent cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Cerebellum violates Marr-Albus predictions to train synapses on long-term anticipatory goals.bioRxiv : the preprint server for biology · 2026Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
There is increasing evidence for a cerebellar contribution to cognitive processing, but the specific input pathways conveying this information remain unclear. We probed the role of climbing fiber inputs to Purkinje cells in generating and evaluating predictions about associations between motor actions, sensory stimuli and reward. We trained mice to perform a visuomotor integration task to receive a reward and interleaved cued and random rewards between task trials. Using two-photon calcium imaging and Neuropixels probe recordings of Purkinje cell activity, we show that climbing fibers signal reward expectation, delivery and omission. These signals map onto cerebellar microzones, with reward delivery activating some microzones and suppressing others, and with reward omission activating both reward-activated and reward-suppressed microzones. Moreover, responses to predictable rewards are progressively suppressed during learning. Our findings elucidate a specific input pathway for cerebellar contributions to reward signaling and provide a mechanistic link between cerebellar activity and the creation and evaluation of predictions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.